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Anti-PRMT5 monoclonal antibody
Pre-made anti-PRMT5 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PRMT5/PRMT5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T82665-Ab-1/ GM-Tg-hg-T82665-Ab-2 | Anti-Human PRMT5 monoclonal antibody | Human |
| GM-Tg-rg-T82665-Ab-1/ GM-Tg-rg-T82665-Ab-2 | Anti-Rat PRMT5 monoclonal antibody | Rat |
| GM-Tg-mg-T82665-Ab-1/ GM-Tg-mg-T82665-Ab-2 | Anti-Mouse PRMT5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T82665-Ab-1/ GM-Tg-cynog-T82665-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRMT5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T82665-Ab-1/ GM-Tg-felg-T82665-Ab-2 | Anti-Feline PRMT5 monoclonal antibody | Feline |
| GM-Tg-cang-T82665-Ab-1/ GM-Tg-cang-T82665-Ab-2 | Anti-Canine PRMT5 monoclonal antibody | Canine |
| GM-Tg-bovg-T82665-Ab-1/ GM-Tg-bovg-T82665-Ab-2 | Anti-Bovine PRMT5 monoclonal antibody | Bovine |
| GM-Tg-equg-T82665-Ab-1/ GM-Tg-equg-T82665-Ab-2 | Anti-Equine PRMT5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T82665-Ab-1/ GM-Tg-hg-T82665-Ab-2; GM-Tg-rg-T82665-Ab-1/ GM-Tg-rg-T82665-Ab-2; GM-Tg-mg-T82665-Ab-1/ GM-Tg-mg-T82665-Ab-2; GM-Tg-cynog-T82665-Ab-1/ GM-Tg-cynog-T82665-Ab-2; GM-Tg-felg-T82665-Ab-1/ GM-Tg-felg-T82665-Ab-2; GM-Tg-cang-T82665-Ab-1/ GM-Tg-cang-T82665-Ab-2; GM-Tg-bovg-T82665-Ab-1/ GM-Tg-bovg-T82665-Ab-2; GM-Tg-equg-T82665-Ab-1/ GM-Tg-equg-T82665-Ab-2 |
| Products Name | Anti-PRMT5 monoclonal antibody |
| Format | mab |
| Target Name | PRMT5 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PRMT5 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T82665-Ag-1 | Recombinant multi-species ANM5/ PRMT5/ HRMT1L5 protein |
| ORF Viral Vector | vGMLV000196 | human PRMT5 Lentivirus particle |
| ORF Viral Vector | vGMAD000192 | human PRMT5 Adenovirus particle |
| ORF Viral Vector | vGMLV000778 | human PRMT5 Lentivirus particle |
| ORF Viral Vector | pGMLV000778 | human PRMT5 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000192 | human PRMT5 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000196 | human PRMT5 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003039 | mouse Prmt5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003039 | mouse Prmt5 Lentivirus particle |
Target information
| Target ID | GM-T82665 |
| Target Name | PRMT5 |
| Gene ID | 10419,27374,364382,712718,480242,101091118,515594,100052729 |
| Gene Symbol and Synonyms | HRMT1L5,HSL7,IBP72,JBP1,PRMT5,SKB1,SKB1Hs |
| Uniprot Accession | O14744,A7YW45 |
| Uniprot Entry Name | ANM5_HUMAN,ANM5_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000100462 |
| Target Classification | N/A |
The target: PRMT5, gene name: PRMT5, also named as HRMT1L5, IBP72, JBP1, SKB1, SKB1Hs. This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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