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Anti-GDF8/ MSTN/ MSLHP functional antibody
Anti-GDF8/ MSTN/ MSLHP functional antibody for cell culture, ELISA & in-vivo assay
Go to MSTN/MSTN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T80024-Ab-1/ GM-Tg-hg-T80024-Ab-2 | Anti-Human MSTN monoclonal antibody | Human |
| GM-Tg-rg-T80024-Ab-1/ GM-Tg-rg-T80024-Ab-2 | Anti-Rat MSTN monoclonal antibody | Rat |
| GM-Tg-mg-T80024-Ab-1/ GM-Tg-mg-T80024-Ab-2 | Anti-Mouse MSTN monoclonal antibody | Mouse |
| GM-Tg-cynog-T80024-Ab-1/ GM-Tg-cynog-T80024-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MSTN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T80024-Ab-1/ GM-Tg-felg-T80024-Ab-2 | Anti-Feline MSTN monoclonal antibody | Feline |
| GM-Tg-cang-T80024-Ab-1/ GM-Tg-cang-T80024-Ab-2 | Anti-Canine MSTN monoclonal antibody | Canine |
| GM-Tg-bovg-T80024-Ab-1/ GM-Tg-bovg-T80024-Ab-2 | Anti-Bovine MSTN monoclonal antibody | Bovine |
| GM-Tg-equg-T80024-Ab-1/ GM-Tg-equg-T80024-Ab-2 | Anti-Equine MSTN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T80024-Ab-1/ GM-Tg-hg-T80024-Ab-2; GM-Tg-rg-T80024-Ab-1/ GM-Tg-rg-T80024-Ab-2; GM-Tg-mg-T80024-Ab-1/ GM-Tg-mg-T80024-Ab-2; GM-Tg-cynog-T80024-Ab-1/ GM-Tg-cynog-T80024-Ab-2; GM-Tg-felg-T80024-Ab-1/ GM-Tg-felg-T80024-Ab-2; GM-Tg-cang-T80024-Ab-1/ GM-Tg-cang-T80024-Ab-2; GM-Tg-bovg-T80024-Ab-1/ GM-Tg-bovg-T80024-Ab-2; GM-Tg-equg-T80024-Ab-1/ GM-Tg-equg-T80024-Ab-2 |
| Products Name | Anti-MSTN monoclonal antibody |
| Format | mab |
| Target Name | MSTN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MSTN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-030 | Pre-Made Apitegromab biosimilar, Whole Mab: Anti-pro-GDF-8 therapeutic antibody |
| Target Antigen | GM-Tg-g-T80024-Ag-1 | Recombinant multi-species GDF8/ MSTN/ MSLHP protein |
| ORF Viral Vector | pGMLPm002174 | mouse Mstn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002174 | mouse Mstn Lentivirus particle |
Target information
| Target ID | GM-T80024 |
| Target Name | MSTN |
| Gene ID | 2660,17700,29152,710114,403433,101081322,281187,100033832 |
| Gene Symbol and Synonyms | Cmpt,GDF8,MSLHP,MSTN |
| Uniprot Accession | O14793,O35312,A1C2U6,Q6UKZ8,O18836,Q9GM97 |
| Uniprot Entry Name | GDF8_HUMAN,GDF8_MACMU,GDF8_RAT,GDF8_CANLF,GDF8_BOVIN,GDF8_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000138379 |
| Target Classification | N/A |
The target: MSTN, gene name: MSTN, also named as GDF8, MSLHP. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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