Anti-LEP/ LEPD/ OB functional antibody

Anti-LEP/ LEPD/ OB functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to LEP/LEP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T79485-Ab-1/ GM-Tg-hg-T79485-Ab-2Anti-Human LEP monoclonal antibodyHuman
GM-Tg-rg-T79485-Ab-1/ GM-Tg-rg-T79485-Ab-2Anti-Rat LEP monoclonal antibodyRat
GM-Tg-mg-T79485-Ab-1/ GM-Tg-mg-T79485-Ab-2Anti-Mouse LEP monoclonal antibodyMouse
GM-Tg-cynog-T79485-Ab-1/ GM-Tg-cynog-T79485-Ab-2Anti-Cynomolgus/ Rhesus macaque LEP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T79485-Ab-1/ GM-Tg-felg-T79485-Ab-2Anti-Feline LEP monoclonal antibodyFeline
GM-Tg-cang-T79485-Ab-1/ GM-Tg-cang-T79485-Ab-2Anti-Canine LEP monoclonal antibodyCanine
GM-Tg-bovg-T79485-Ab-1/ GM-Tg-bovg-T79485-Ab-2Anti-Bovine LEP monoclonal antibodyBovine
GM-Tg-equg-T79485-Ab-1/ GM-Tg-equg-T79485-Ab-2Anti-Equine LEP monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T79485-Ab-1/ GM-Tg-hg-T79485-Ab-2; GM-Tg-rg-T79485-Ab-1/ GM-Tg-rg-T79485-Ab-2;
GM-Tg-mg-T79485-Ab-1/ GM-Tg-mg-T79485-Ab-2; GM-Tg-cynog-T79485-Ab-1/ GM-Tg-cynog-T79485-Ab-2;
GM-Tg-felg-T79485-Ab-1/ GM-Tg-felg-T79485-Ab-2; GM-Tg-cang-T79485-Ab-1/ GM-Tg-cang-T79485-Ab-2;
GM-Tg-bovg-T79485-Ab-1/ GM-Tg-bovg-T79485-Ab-2; GM-Tg-equg-T79485-Ab-1/ GM-Tg-equg-T79485-Ab-2
Products NameAnti-LEP monoclonal antibody
Formatmab
Target NameLEP
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LEP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T79485-Ag-1Recombinant multi-species LEP/ LEPD/ OB protein
    CytokineGM-Tg-g-T79485-Ag-1leptin (LEP) protein
    ORF Viral VectorpGMLP001963human LEP Lentivirus plasmid
    ORF Viral VectorvGMLP001963human LEP Lentivirus particle
    ORF Viral VectorpGMAD000615house mouse Lep Adenovirus plasmid
    ORF Viral VectorpGMLPm000126mouse Lep Lentivirus plasmid
    ORF Viral VectorvGMAD000615house mouse Lep Adenovirus particle
    ORF Viral VectorvGMLPm000126mouse Lep Lentivirus particle


    Target information

    Target IDGM-T79485
    Target NameLEP
    Gene ID3952,16846,25608,698728,403616,493838,280836,100034042
    Gene Symbol and SynonymsLEP,LEPD,OB,obese,OBS
    Uniprot AccessionP41159,P50596,Q28504,O02720,Q9N2C1,P50595,Q9TU09
    Uniprot Entry NameLEP_HUMAN,LEP_MACMU,LEP_RAT,LEP_FELCA,LEP_CANLF,LEP_BOVIN,LEP_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000174697
    Target ClassificationN/A

    The target: LEP, gene name: LEP, also named as LEPD, OB, OBS. This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.