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Anti-GDNF/ ATF/ ATF1 functional antibody
Anti-GDNF/ ATF/ ATF1 functional antibody for cell culture, ELISA & in-vivo assay
Go to GDNF/GDNF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T79160-Ab-1/ GM-Tg-hg-T79160-Ab-2 | Anti-Human GDNF monoclonal antibody | Human |
| GM-Tg-rg-T79160-Ab-1/ GM-Tg-rg-T79160-Ab-2 | Anti-Rat GDNF monoclonal antibody | Rat |
| GM-Tg-mg-T79160-Ab-1/ GM-Tg-mg-T79160-Ab-2 | Anti-Mouse GDNF monoclonal antibody | Mouse |
| GM-Tg-cynog-T79160-Ab-1/ GM-Tg-cynog-T79160-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GDNF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T79160-Ab-1/ GM-Tg-felg-T79160-Ab-2 | Anti-Feline GDNF monoclonal antibody | Feline |
| GM-Tg-cang-T79160-Ab-1/ GM-Tg-cang-T79160-Ab-2 | Anti-Canine GDNF monoclonal antibody | Canine |
| GM-Tg-bovg-T79160-Ab-1/ GM-Tg-bovg-T79160-Ab-2 | Anti-Bovine GDNF monoclonal antibody | Bovine |
| GM-Tg-equg-T79160-Ab-1/ GM-Tg-equg-T79160-Ab-2 | Anti-Equine GDNF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T79160-Ab-1/ GM-Tg-hg-T79160-Ab-2; GM-Tg-rg-T79160-Ab-1/ GM-Tg-rg-T79160-Ab-2; GM-Tg-mg-T79160-Ab-1/ GM-Tg-mg-T79160-Ab-2; GM-Tg-cynog-T79160-Ab-1/ GM-Tg-cynog-T79160-Ab-2; GM-Tg-felg-T79160-Ab-1/ GM-Tg-felg-T79160-Ab-2; GM-Tg-cang-T79160-Ab-1/ GM-Tg-cang-T79160-Ab-2; GM-Tg-bovg-T79160-Ab-1/ GM-Tg-bovg-T79160-Ab-2; GM-Tg-equg-T79160-Ab-1/ GM-Tg-equg-T79160-Ab-2 |
| Products Name | Anti-GDNF monoclonal antibody |
| Format | mab |
| Target Name | GDNF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GDNF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T79160-Ag-1 | Recombinant multi-species GDNF/ ATF/ ATF1 protein |
| Cytokine | GM-Tg-g-T79160-Ag-1 | glial cell derived neurotrophic factor (GDNF) protein |
| ORF Viral Vector | pGMLP002678 | human GDNF Lentivirus plasmid |
| ORF Viral Vector | pGMLV000366 | human GDNF Lentivirus plasmid |
| ORF Viral Vector | vGMLV000366 | human GDNF Lentivirus particle |
| ORF Viral Vector | vGMLV000484 | human GDNF Lentivirus particle |
| ORF Viral Vector | pGMLV000484 | human GDNF Lentivirus plasmid |
| ORF Viral Vector | vGMLP002678 | human GDNF Lentivirus particle |
| ORF Viral Vector | pGMLV000093 | rat Gdnf Lentivirus plasmid |
| ORF Viral Vector | pGMLV000814 | Norway rat Gdnf Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000285 | house mouse Gdnf AAV plasmid |
| ORF Viral Vector | pGMLPm000319 | mouse Gdnf Lentivirus plasmid |
| ORF Viral Vector | vGMLV000093 | rat Gdnf Lentivirus particle |
| ORF Viral Vector | vGMLV000814 | Norway rat Gdnf Lentivirus particle |
| ORF Viral Vector | vGMAAV000285 | house mouse Gdnf AAV particle |
| ORF Viral Vector | vGMLPm000319 | mouse Gdnf Lentivirus particle |
Target information
| Target ID | GM-T79160 |
| Target Name | GDNF |
| Gene ID | 2668,14573,25453,706345,119871563,101097871,386587,100067053 |
| Gene Symbol and Synonyms | ATF,ATF1,ATF2,GDNF,gndf,HFB1-GDNF,HSCR3 |
| Uniprot Accession | P39905,Q07731 |
| Uniprot Entry Name | GDNF_HUMAN,GDNF_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000168621 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: GDNF, gene name: GDNF, also named as ATF, ATF1, ATF2, HFB1-GDNF, HSCR3. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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