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Anti-5HT1A/ HTR1A/ 5-HT-1A monoclonal antibody
Anti-5HT1A/ HTR1A/ 5-HT-1A antibody for FACS & in-vivo assay
Go to HTR1A/HTR1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T78709-Ab-1/ GM-Tg-hg-T78709-Ab-2 | Anti-Human HTR1A monoclonal antibody | Human |
| GM-Tg-rg-T78709-Ab-1/ GM-Tg-rg-T78709-Ab-2 | Anti-Rat HTR1A monoclonal antibody | Rat |
| GM-Tg-mg-T78709-Ab-1/ GM-Tg-mg-T78709-Ab-2 | Anti-Mouse HTR1A monoclonal antibody | Mouse |
| GM-Tg-cynog-T78709-Ab-1/ GM-Tg-cynog-T78709-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTR1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T78709-Ab-1/ GM-Tg-felg-T78709-Ab-2 | Anti-Feline HTR1A monoclonal antibody | Feline |
| GM-Tg-cang-T78709-Ab-1/ GM-Tg-cang-T78709-Ab-2 | Anti-Canine HTR1A monoclonal antibody | Canine |
| GM-Tg-bovg-T78709-Ab-1/ GM-Tg-bovg-T78709-Ab-2 | Anti-Bovine HTR1A monoclonal antibody | Bovine |
| GM-Tg-equg-T78709-Ab-1/ GM-Tg-equg-T78709-Ab-2 | Anti-Equine HTR1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T78709-Ab-1/ GM-Tg-hg-T78709-Ab-2; GM-Tg-rg-T78709-Ab-1/ GM-Tg-rg-T78709-Ab-2; GM-Tg-mg-T78709-Ab-1/ GM-Tg-mg-T78709-Ab-2; GM-Tg-cynog-T78709-Ab-1/ GM-Tg-cynog-T78709-Ab-2; GM-Tg-felg-T78709-Ab-1/ GM-Tg-felg-T78709-Ab-2; GM-Tg-cang-T78709-Ab-1/ GM-Tg-cang-T78709-Ab-2; GM-Tg-bovg-T78709-Ab-1/ GM-Tg-bovg-T78709-Ab-2; GM-Tg-equg-T78709-Ab-1/ GM-Tg-equg-T78709-Ab-2 |
| Products Name | Anti-HTR1A monoclonal antibody |
| Format | mab |
| Target Name | HTR1A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HTR1A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species 5HT1A/ HTR1A/ 5-HT-1A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003677 | human HTR1A Lentivirus plasmid |
| ORF Viral Vector | vGMLP003677 | human HTR1A Lentivirus particle |
| ORF Viral Vector | pGMLPm002988 | mouse Htr1a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002988 | mouse Htr1a Lentivirus particle |
Target information
| Target ID | GM-T78709 |
| Target Name | HTR1A |
| Gene ID | 3350,15550,24473,694991,487230,101101542,407137,100009683 |
| Gene Symbol and Synonyms | 5-HT-1A,5-HT1A,5HT1a,5htr1a,ADRB2RL1,ADRBRL1,G-21,Gpcr18,HTR1A,PFMCD,RAT5HT1A |
| Uniprot Accession | P08908,P19327,Q6XXX9,Q0EAB6 |
| Uniprot Entry Name | 5HT1A_HUMAN,5HT1A_RAT,5HT1A_CANLF,5HT1A_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000178394 |
| Target Classification | GPCR |
The target: HTR1A, gene name: HTR1A, also named as 5-HT-1A, 5-HT1A, 5HT1a, ADRB2RL1, ADRBRL1, G-21, PFMCD. This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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