Anti-HsPEK monoclonal antibody

Pre-made anti-HsPEK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to HsPEK/EIF2AK3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T75015-Ab-1/ GM-Tg-hg-T75015-Ab-2Anti-Human HsPEK/EIF2AK3 monoclonal antibodyHuman
GM-Tg-rg-T75015-Ab-1/ GM-Tg-rg-T75015-Ab-2Anti-Rat HsPEK/EIF2AK3 monoclonal antibodyRat
GM-Tg-mg-T75015-Ab-1/ GM-Tg-mg-T75015-Ab-2Anti-Mouse HsPEK/EIF2AK3 monoclonal antibodyMouse
GM-Tg-cynog-T75015-Ab-1/ GM-Tg-cynog-T75015-Ab-2Anti-Cynomolgus/ Rhesus macaque HsPEK/EIF2AK3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T75015-Ab-1/ GM-Tg-felg-T75015-Ab-2Anti-Feline HsPEK/EIF2AK3 monoclonal antibodyFeline
GM-Tg-cang-T75015-Ab-1/ GM-Tg-cang-T75015-Ab-2Anti-Canine HsPEK/EIF2AK3 monoclonal antibodyCanine
GM-Tg-bovg-T75015-Ab-1/ GM-Tg-bovg-T75015-Ab-2Anti-Bovine HsPEK/EIF2AK3 monoclonal antibodyBovine
GM-Tg-equg-T75015-Ab-1/ GM-Tg-equg-T75015-Ab-2Anti-Equine HsPEK/EIF2AK3 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T75015-Ab-1/ GM-Tg-hg-T75015-Ab-2; GM-Tg-rg-T75015-Ab-1/ GM-Tg-rg-T75015-Ab-2;
GM-Tg-mg-T75015-Ab-1/ GM-Tg-mg-T75015-Ab-2; GM-Tg-cynog-T75015-Ab-1/ GM-Tg-cynog-T75015-Ab-2;
GM-Tg-felg-T75015-Ab-1/ GM-Tg-felg-T75015-Ab-2; GM-Tg-cang-T75015-Ab-1/ GM-Tg-cang-T75015-Ab-2;
GM-Tg-bovg-T75015-Ab-1/ GM-Tg-bovg-T75015-Ab-2; GM-Tg-equg-T75015-Ab-1/ GM-Tg-equg-T75015-Ab-2
Products NameAnti-HsPEK/EIF2AK3 monoclonal antibody
Formatmab
Target NameHsPEK
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-HsPEK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T75015-Ag-1Recombinant multi-species E2AK3/ HsPEK/ EIF2AK3 protein


    Target information

    Target IDGM-T75015
    Target NameHsPEK
    Gene ID9451,13666,29702,699575,475756,101095973,535820,100066488
    Gene Symbol and SynonymsEIF2AK3,PEK,PERK,WRS
    Uniprot AccessionQ9NZJ5,Q9Z1Z1
    Uniprot Entry NameE2AK3_HUMAN,E2AK3_RAT
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000172071
    Target ClassificationN/A

    The target: HsPEK, gene name: EIF2AK3, also named as PEK, PERK, WRS. The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.