Anti-KCNJ2/ ATFB9/ HHBIRK1 monoclonal antibody

Anti-KCNJ2/ ATFB9/ HHBIRK1 antibody for FACS & in-vivo assay

Target products collectionGo to KCNJ2/KCNJ2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T74570-Ab-1/ GM-Tg-hg-T74570-Ab-2Anti-Human KCNJ2 monoclonal antibodyHuman
GM-Tg-rg-T74570-Ab-1/ GM-Tg-rg-T74570-Ab-2Anti-Rat KCNJ2 monoclonal antibodyRat
GM-Tg-mg-T74570-Ab-1/ GM-Tg-mg-T74570-Ab-2Anti-Mouse KCNJ2 monoclonal antibodyMouse
GM-Tg-cynog-T74570-Ab-1/ GM-Tg-cynog-T74570-Ab-2Anti-Cynomolgus/ Rhesus macaque KCNJ2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T74570-Ab-1/ GM-Tg-felg-T74570-Ab-2Anti-Feline KCNJ2 monoclonal antibodyFeline
GM-Tg-cang-T74570-Ab-1/ GM-Tg-cang-T74570-Ab-2Anti-Canine KCNJ2 monoclonal antibodyCanine
GM-Tg-bovg-T74570-Ab-1/ GM-Tg-bovg-T74570-Ab-2Anti-Bovine KCNJ2 monoclonal antibodyBovine
GM-Tg-equg-T74570-Ab-1/ GM-Tg-equg-T74570-Ab-2Anti-Equine KCNJ2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T74570-Ab-1/ GM-Tg-hg-T74570-Ab-2; GM-Tg-rg-T74570-Ab-1/ GM-Tg-rg-T74570-Ab-2;
GM-Tg-mg-T74570-Ab-1/ GM-Tg-mg-T74570-Ab-2; GM-Tg-cynog-T74570-Ab-1/ GM-Tg-cynog-T74570-Ab-2;
GM-Tg-felg-T74570-Ab-1/ GM-Tg-felg-T74570-Ab-2; GM-Tg-cang-T74570-Ab-1/ GM-Tg-cang-T74570-Ab-2;
GM-Tg-bovg-T74570-Ab-1/ GM-Tg-bovg-T74570-Ab-2; GM-Tg-equg-T74570-Ab-1/ GM-Tg-equg-T74570-Ab-2
Products NameAnti-KCNJ2 monoclonal antibody
Formatmab
Target NameKCNJ2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-KCNJ2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species KCNJ2/ ATFB9/ HHBIRK1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP003142human KCNJ2 Lentivirus particle
    ORF Viral VectorpGMLP003142human KCNJ2 Lentivirus plasmid
    ORF Viral VectorpGMLV000106rat Kcnj2 Lentivirus plasmid
    ORF Viral VectorpGMLV000603Norway rat Kcnj2 Lentivirus plasmid
    ORF Viral VectorpGMLPm005332mouse Kcnj2 Lentivirus plasmid
    ORF Viral VectorvGMLV000106rat Kcnj2 Lentivirus particle
    ORF Viral VectorvGMLV000603Norway rat Kcnj2 Lentivirus particle
    ORF Viral VectorvGMLPm005332mouse Kcnj2 Lentivirus particle


    Target information

    Target IDGM-T74570
    Target NameKCNJ2
    Gene ID3759,16518,29712,574189,403717,101090306,281883,100052953
    Gene Symbol and SynonymsATFB9,HHBIRK1,HHIRK1,IRK1,Kcnf1,KCNJ2,KIR2.1,LQT7,SQT3
    Uniprot AccessionP63252,Q64273,P63253,Q9MYY9,O19182
    Uniprot Entry NameKCNJ2_HUMAN,KCNJ2_MACMU,KCNJ2_RAT,KCNJ2_CANLF,KCNJ2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000123700
    Target ClassificationIon Channel

    The target: KCNJ2, gene name: KCNJ2, also named as ATFB9, HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7, SQT3. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.