Anti-UPAR/ PLAUR/ CD87 monoclonal antibody

Anti-UPAR/ PLAUR/ CD87 antibody for FACS & in-vivo assay

Target products collectionGo to PLAUR/PLAUR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T74363-Ab-1/ GM-Tg-hg-T74363-Ab-2Anti-Human PLAUR monoclonal antibodyHuman
GM-Tg-rg-T74363-Ab-1/ GM-Tg-rg-T74363-Ab-2Anti-Rat PLAUR monoclonal antibodyRat
GM-Tg-mg-T74363-Ab-1/ GM-Tg-mg-T74363-Ab-2Anti-Mouse PLAUR monoclonal antibodyMouse
GM-Tg-cynog-T74363-Ab-1/ GM-Tg-cynog-T74363-Ab-2Anti-Cynomolgus/ Rhesus macaque PLAUR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T74363-Ab-1/ GM-Tg-felg-T74363-Ab-2Anti-Feline PLAUR monoclonal antibodyFeline
GM-Tg-cang-T74363-Ab-1/ GM-Tg-cang-T74363-Ab-2Anti-Canine PLAUR monoclonal antibodyCanine
GM-Tg-bovg-T74363-Ab-1/ GM-Tg-bovg-T74363-Ab-2Anti-Bovine PLAUR monoclonal antibodyBovine
GM-Tg-equg-T74363-Ab-1/ GM-Tg-equg-T74363-Ab-2Anti-Equine PLAUR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T74363-Ab-1/ GM-Tg-hg-T74363-Ab-2; GM-Tg-rg-T74363-Ab-1/ GM-Tg-rg-T74363-Ab-2;
GM-Tg-mg-T74363-Ab-1/ GM-Tg-mg-T74363-Ab-2; GM-Tg-cynog-T74363-Ab-1/ GM-Tg-cynog-T74363-Ab-2;
GM-Tg-felg-T74363-Ab-1/ GM-Tg-felg-T74363-Ab-2; GM-Tg-cang-T74363-Ab-1/ GM-Tg-cang-T74363-Ab-2;
GM-Tg-bovg-T74363-Ab-1/ GM-Tg-bovg-T74363-Ab-2; GM-Tg-equg-T74363-Ab-1/ GM-Tg-equg-T74363-Ab-2
Products NameAnti-PLAUR monoclonal antibody
Formatmab
Target NamePLAUR
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PLAUR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species UPAR/ PLAUR/ CD87 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMAP000173Human PLAUR Adenovirus particle
    ORF Viral VectorpGMAP000173Human PLAUR Adenovirus plasmid
    ORF Viral VectorpGMLPm001286mouse Plaur Lentivirus plasmid
    ORF Viral VectorvGMLPm001286mouse Plaur Lentivirus particle


    Target information

    Target IDGM-T74363
    Target NamePLAUR
    Gene ID5329,18793,50692,710662,101091240,281983,100033904
    Gene Symbol and SynonymsCD87,Par,PLAUR,Plaur3,U-PAR,UPAR,uPAR-2,uPAR-3,URKR
    Uniprot AccessionQ03405,P49616,Q05588
    Uniprot Entry NameUPAR_HUMAN,UPAR_RAT,UPAR_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseNephrotic syndrome with focal and segmental glomerular lesions, Kidney transplant rejection, Chronic Kidney Disease
    Gene EnsemblENSG00000011422
    Target ClassificationN/A

    The target: PLAUR, gene name: PLAUR, also named as CD87, U-PAR, UPAR, URKR. This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008].



    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.