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Anti-BMI1 monoclonal antibody
Pre-made anti-BMI1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to BMI1/BMI1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T74066-Ab-1/ GM-Tg-hg-T74066-Ab-2 | Anti-Human BMI1 monoclonal antibody | Human |
| GM-Tg-rg-T74066-Ab-1/ GM-Tg-rg-T74066-Ab-2 | Anti-Rat BMI1 monoclonal antibody | Rat |
| GM-Tg-mg-T74066-Ab-1/ GM-Tg-mg-T74066-Ab-2 | Anti-Mouse BMI1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T74066-Ab-1/ GM-Tg-cynog-T74066-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BMI1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T74066-Ab-1/ GM-Tg-felg-T74066-Ab-2 | Anti-Feline BMI1 monoclonal antibody | Feline |
| GM-Tg-cang-T74066-Ab-1/ GM-Tg-cang-T74066-Ab-2 | Anti-Canine BMI1 monoclonal antibody | Canine |
| GM-Tg-bovg-T74066-Ab-1/ GM-Tg-bovg-T74066-Ab-2 | Anti-Bovine BMI1 monoclonal antibody | Bovine |
| GM-Tg-equg-T74066-Ab-1/ GM-Tg-equg-T74066-Ab-2 | Anti-Equine BMI1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T74066-Ab-1/ GM-Tg-hg-T74066-Ab-2; GM-Tg-rg-T74066-Ab-1/ GM-Tg-rg-T74066-Ab-2; GM-Tg-mg-T74066-Ab-1/ GM-Tg-mg-T74066-Ab-2; GM-Tg-cynog-T74066-Ab-1/ GM-Tg-cynog-T74066-Ab-2; GM-Tg-felg-T74066-Ab-1/ GM-Tg-felg-T74066-Ab-2; GM-Tg-cang-T74066-Ab-1/ GM-Tg-cang-T74066-Ab-2; GM-Tg-bovg-T74066-Ab-1/ GM-Tg-bovg-T74066-Ab-2; GM-Tg-equg-T74066-Ab-1/ GM-Tg-equg-T74066-Ab-2 |
| Products Name | Anti-BMI1 monoclonal antibody |
| Format | mab |
| Target Name | BMI1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-BMI1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T74066-Ag-1 | Recombinant multi-species BMI1/ FLVI2/BMI1/ PCGF4 protein |
| ORF Viral Vector | vGMLV000219 | human BMI1 Lentivirus particle |
| ORF Viral Vector | pGMLV000219 | human BMI1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000312 | mouse Bmi1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000312 | mouse Bmi1 Lentivirus particle |
Target information
| Target ID | GM-T74066 |
| Target Name | BMI1 |
| Gene ID | 648,12151,307151,106992288,487097,554342,510666 |
| Gene Symbol and Synonyms | Bmi-1,BMI1,flvi-2/bmi-1,FLVI2/BMI1,PCGF4,RNF51 |
| Uniprot Accession | P35226,Q9TST0,Q32KX7 |
| Uniprot Entry Name | BMI1_HUMAN,BMI1_FELCA,BMI1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000168283 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: BMI1, gene name: BMI1, also named as FLVI2/BMI1, PCGF4, RNF51, flvi-2/bmi-1. This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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