Anti-IL1R1/ CD121A/ D2S1473 monoclonal antibody

Anti-IL1R1/ CD121A/ D2S1473 antibody for FACS & in-vivo assay

Target products collectionGo to IL1R1/IL1R1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T72515-Ab-1/ GM-Tg-hg-T72515-Ab-2Anti-Human IL1R1 monoclonal antibodyHuman
GM-Tg-rg-T72515-Ab-1/ GM-Tg-rg-T72515-Ab-2Anti-Rat IL1R1 monoclonal antibodyRat
GM-Tg-mg-T72515-Ab-1/ GM-Tg-mg-T72515-Ab-2Anti-Mouse IL1R1 monoclonal antibodyMouse
GM-Tg-cynog-T72515-Ab-1/ GM-Tg-cynog-T72515-Ab-2Anti-Cynomolgus/ Rhesus macaque IL1R1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T72515-Ab-1/ GM-Tg-felg-T72515-Ab-2Anti-Feline IL1R1 monoclonal antibodyFeline
GM-Tg-cang-T72515-Ab-1/ GM-Tg-cang-T72515-Ab-2Anti-Canine IL1R1 monoclonal antibodyCanine
GM-Tg-bovg-T72515-Ab-1/ GM-Tg-bovg-T72515-Ab-2Anti-Bovine IL1R1 monoclonal antibodyBovine
GM-Tg-equg-T72515-Ab-1/ GM-Tg-equg-T72515-Ab-2Anti-Equine IL1R1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T72515-Ab-1/ GM-Tg-hg-T72515-Ab-2; GM-Tg-rg-T72515-Ab-1/ GM-Tg-rg-T72515-Ab-2;
GM-Tg-mg-T72515-Ab-1/ GM-Tg-mg-T72515-Ab-2; GM-Tg-cynog-T72515-Ab-1/ GM-Tg-cynog-T72515-Ab-2;
GM-Tg-felg-T72515-Ab-1/ GM-Tg-felg-T72515-Ab-2; GM-Tg-cang-T72515-Ab-1/ GM-Tg-cang-T72515-Ab-2;
GM-Tg-bovg-T72515-Ab-1/ GM-Tg-bovg-T72515-Ab-2; GM-Tg-equg-T72515-Ab-1/ GM-Tg-equg-T72515-Ab-2
Products NameAnti-IL1R1 monoclonal antibody
Formatmab
Target NameIL1R1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL1R1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-732Pre-Made Anakinra Biosimilar, Recombinant Protein targeting IL1R1: Recombinant therapeutic protein targeting CD121A/D2S1473/IL-1R-alpha/IL1R/IL1RA/P80 Pre-made [INN Name] Biosimilar, [Format] targeting [Target1/Target2]: Recombinant therapeutic protein targeting [alias1/Alias2]
    Target AntigenProducts DevelopingMulti-species IL1R1/ CD121A/ D2S1473 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T72515-Ag-1interleukin 1 receptor, type I (IL1R1) protein
    ORF Viral VectorpGMLPm004959mouse Il1r1 Lentivirus plasmid
    ORF Viral VectorvGMLPm004959mouse Il1r1 Lentivirus particle


    Target information

    Target IDGM-T72515
    Target NameIL1R1
    Gene ID3554,16177,25663,711726,481328,101080705,515640,100009699
    Gene Symbol and SynonymsCD121A,CD121b,D2S1473,IL-1R-1,IL-1R-alpha,IL-1R1,IL-1RT-1,IL-1RT1,IL-iR,IL1R,Il1r-1,IL1R1,IL1RA,P80
    Uniprot AccessionP14778,Q02955
    Uniprot Entry NameIL1R1_HUMAN,IL1R1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000115594
    Target ClassificationCheckpoint-Immuno Oncology

    The target: IL1R1, gene name: IL1R1, also named as CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80. This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.