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Anti-IL36G/ IL-1F9/ IL-1H1 monoclonal antibody
Anti-IL36G/ IL-1F9/ IL-1H1 antibody for FACS & in-vivo assay
Go to IL36G/IL36G products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T72514-Ab-1/ GM-Tg-hg-T72514-Ab-2 | Anti-Human IL36G monoclonal antibody | Human |
| GM-Tg-rg-T72514-Ab-1/ GM-Tg-rg-T72514-Ab-2 | Anti-Rat IL36G monoclonal antibody | Rat |
| GM-Tg-mg-T72514-Ab-1/ GM-Tg-mg-T72514-Ab-2 | Anti-Mouse IL36G monoclonal antibody | Mouse |
| GM-Tg-cynog-T72514-Ab-1/ GM-Tg-cynog-T72514-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL36G monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T72514-Ab-1/ GM-Tg-felg-T72514-Ab-2 | Anti-Feline IL36G monoclonal antibody | Feline |
| GM-Tg-cang-T72514-Ab-1/ GM-Tg-cang-T72514-Ab-2 | Anti-Canine IL36G monoclonal antibody | Canine |
| GM-Tg-bovg-T72514-Ab-1/ GM-Tg-bovg-T72514-Ab-2 | Anti-Bovine IL36G monoclonal antibody | Bovine |
| GM-Tg-equg-T72514-Ab-1/ GM-Tg-equg-T72514-Ab-2 | Anti-Equine IL36G monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T72514-Ab-1/ GM-Tg-hg-T72514-Ab-2; GM-Tg-rg-T72514-Ab-1/ GM-Tg-rg-T72514-Ab-2; GM-Tg-mg-T72514-Ab-1/ GM-Tg-mg-T72514-Ab-2; GM-Tg-cynog-T72514-Ab-1/ GM-Tg-cynog-T72514-Ab-2; GM-Tg-felg-T72514-Ab-1/ GM-Tg-felg-T72514-Ab-2; GM-Tg-cang-T72514-Ab-1/ GM-Tg-cang-T72514-Ab-2; GM-Tg-bovg-T72514-Ab-1/ GM-Tg-bovg-T72514-Ab-2; GM-Tg-equg-T72514-Ab-1/ GM-Tg-equg-T72514-Ab-2 |
| Products Name | Anti-IL36G monoclonal antibody |
| Format | mab |
| Target Name | IL36G |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL36G benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species IL36G/ IL-1F9/ IL-1H1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T72514-Ag-1 | interleukin 36, gamma (IL36G) protein |
| ORF Viral Vector | pGMLP003211 | human IL36G Lentivirus plasmid |
| ORF Viral Vector | vGMLP003211 | human IL36G Lentivirus particle |
Target information
| Target ID | GM-T72514 |
| Target Name | IL36G |
| Gene ID | 56300,215257,499744,700822,100686137,101081377,615762 |
| Gene Symbol and Synonyms | If36g,IL-1F9,IL-1H1,IL-1RP2,IL-36gamma,IL1E,IL1F9,IL1H1,IL1RP2,IL36G,RGD1563019 |
| Uniprot Accession | Q9NZH8 |
| Uniprot Entry Name | IL36G_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000136688 |
| Target Classification | N/A |
The target: IL36G, gene name: IL36G, also named as IL-1F9, IL-1H1, IL-1RP2, IL1E, IL1F9, IL1H1, IL1RP2. The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, May 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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