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Anti-IBP7/ IGFBP7/ AGM functional antibody
Anti-IBP7/ IGFBP7/ AGM functional antibody for cell culture, ELISA & in-vivo assay
Go to IGFBP7/IGFBP7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T69271-Ab-1/ GM-Tg-hg-T69271-Ab-2 | Anti-Human IGFBP7 monoclonal antibody | Human |
| GM-Tg-rg-T69271-Ab-1/ GM-Tg-rg-T69271-Ab-2 | Anti-Rat IGFBP7 monoclonal antibody | Rat |
| GM-Tg-mg-T69271-Ab-1/ GM-Tg-mg-T69271-Ab-2 | Anti-Mouse IGFBP7 monoclonal antibody | Mouse |
| GM-Tg-cynog-T69271-Ab-1/ GM-Tg-cynog-T69271-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGFBP7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T69271-Ab-1/ GM-Tg-felg-T69271-Ab-2 | Anti-Feline IGFBP7 monoclonal antibody | Feline |
| GM-Tg-cang-T69271-Ab-1/ GM-Tg-cang-T69271-Ab-2 | Anti-Canine IGFBP7 monoclonal antibody | Canine |
| GM-Tg-bovg-T69271-Ab-1/ GM-Tg-bovg-T69271-Ab-2 | Anti-Bovine IGFBP7 monoclonal antibody | Bovine |
| GM-Tg-equg-T69271-Ab-1/ GM-Tg-equg-T69271-Ab-2 | Anti-Equine IGFBP7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T69271-Ab-1/ GM-Tg-hg-T69271-Ab-2; GM-Tg-rg-T69271-Ab-1/ GM-Tg-rg-T69271-Ab-2; GM-Tg-mg-T69271-Ab-1/ GM-Tg-mg-T69271-Ab-2; GM-Tg-cynog-T69271-Ab-1/ GM-Tg-cynog-T69271-Ab-2; GM-Tg-felg-T69271-Ab-1/ GM-Tg-felg-T69271-Ab-2; GM-Tg-cang-T69271-Ab-1/ GM-Tg-cang-T69271-Ab-2; GM-Tg-bovg-T69271-Ab-1/ GM-Tg-bovg-T69271-Ab-2; GM-Tg-equg-T69271-Ab-1/ GM-Tg-equg-T69271-Ab-2 |
| Products Name | Anti-IGFBP7 monoclonal antibody |
| Format | mab |
| Target Name | IGFBP7 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGFBP7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T69271-Ag-1 | Recombinant multi-species IBP7/ IGFBP7/ AGM protein |
| Cytokine | GM-Tg-g-T69271-Ag-1 | insulin-like growth factor binding protein 7 (IGFBP7) protein |
| ORF Viral Vector | vGMLP003505 | human IGFBP7 Lentivirus particle |
| ORF Viral Vector | pGMLP003505 | human IGFBP7 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000076 | mouse Igfbp7 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000533 | house mouse Igfbp7 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000076 | mouse Igfbp7 Adenovirus particle |
| ORF Viral Vector | vGMAD000533 | house mouse Igfbp7 Adenovirus particle |
Target information
| Target ID | GM-T69271 |
| Target Name | IGFBP7 |
| Gene ID | 3490,29817,289560,693564,608559,101083263,616368,100033844 |
| Gene Symbol and Synonyms | AGM,FSTL2,IBP-7,IGFBP-7,IGFBP-7v,IGFBP7,IGFBPRP1,MAC25,PSF,RAMSVPS,TAF |
| Uniprot Accession | Q16270 |
| Uniprot Entry Name | IBP7_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Dent disease, Heart failure, Acute kidney failure |
| Gene Ensembl | ENSG00000163453 |
| Target Classification | N/A |
The target: IGFBP7, gene name: IGFBP7, also named as AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF. This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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