Anti-MMP2/ MMP-2/ CLG4 monoclonal antibody
Anti-MMP2/ MMP-2/ CLG4 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T68251-Ab-1/ GM-Tg-hg-T68251-Ab-2 | Anti-Human MMP-2/MMP2 monoclonal antibody | Human |
GM-Tg-rg-T68251-Ab-1/ GM-Tg-rg-T68251-Ab-2 | Anti-Rat MMP-2/MMP2 monoclonal antibody | Rat |
GM-Tg-mg-T68251-Ab-1/ GM-Tg-mg-T68251-Ab-2 | Anti-Mouse MMP-2/MMP2 monoclonal antibody | Mouse |
GM-Tg-cynog-T68251-Ab-1/ GM-Tg-cynog-T68251-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MMP-2/MMP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T68251-Ab-1/ GM-Tg-felg-T68251-Ab-2 | Anti-Feline MMP-2/MMP2 monoclonal antibody | Feline |
GM-Tg-cang-T68251-Ab-1/ GM-Tg-cang-T68251-Ab-2 | Anti-Canine MMP-2/MMP2 monoclonal antibody | Canine |
GM-Tg-bovg-T68251-Ab-1/ GM-Tg-bovg-T68251-Ab-2 | Anti-Bovine MMP-2/MMP2 monoclonal antibody | Bovine |
GM-Tg-equg-T68251-Ab-1/ GM-Tg-equg-T68251-Ab-2 | Anti-Equine MMP-2/MMP2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T68251-Ab-1/ GM-Tg-hg-T68251-Ab-2; GM-Tg-rg-T68251-Ab-1/ GM-Tg-rg-T68251-Ab-2; GM-Tg-mg-T68251-Ab-1/ GM-Tg-mg-T68251-Ab-2; GM-Tg-cynog-T68251-Ab-1/ GM-Tg-cynog-T68251-Ab-2; GM-Tg-felg-T68251-Ab-1/ GM-Tg-felg-T68251-Ab-2; GM-Tg-cang-T68251-Ab-1/ GM-Tg-cang-T68251-Ab-2; GM-Tg-bovg-T68251-Ab-1/ GM-Tg-bovg-T68251-Ab-2; GM-Tg-equg-T68251-Ab-1/ GM-Tg-equg-T68251-Ab-2 |
Products Name | Anti-MMP-2/MMP2 monoclonal antibody |
Format | mab |
Target Name | MMP-2 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-MMP-2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species MMP2/ MMP-2/ CLG4 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLP001345 | human NM_004530humanNM_004530 Lentivirus plasmid |
ORF Viral Vector | pGMAP000238 | Human MMP2 Adenovirus plasmid |
ORF Viral Vector | vGMAP000238 | Human MMP2 Adenovirus particle |
ORF Viral Vector | vGMLP001345 | human NM_004530humanNM_004530 Lentivirus particle |
ORF Viral Vector | pGMAAV000161 | mouse Mmp2 AAV plasmid |
ORF Viral Vector | vGMAAV000161 | mouse Mmp2 AAV particle |
Target information
Target ID | GM-T68251 |
Target Name | MMP-2 |
Gene ID | 4313,17390,81686,698478,403733,101098838,282872,100033948 |
Gene Symbol and Synonyms | CLG4,CLG4A,GelA,MMP-2,MMP-II,MMP2,MONA,TBE-1 |
Uniprot Accession | P08253,P33436,Q9GLE5 |
Uniprot Entry Name | MMP2_HUMAN,MMP2_RAT,MMP2_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | Ovary Cancer, Neoplasm, Type 1 diabetes mellitus, Vesicoureteral reflux, Alport syndrome, Chronic Kidney Disease, Chronic tubulo-interstitial nephritis, Malignant neoplasm of bladder, Malignant neoplasms of female genital organs |
Gene Ensembl | ENSG00000087245 |
Target Classification | Checkpoint-Immuno Oncology |
The target: MMP-2, gene name: MMP2, also named as CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1. This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.