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Anti-CD70/ CD27-L/ CD27L monoclonal antibody
Anti-CD70/ CD27-L/ CD27L antibody for FACS & in-vivo assay
Go to CD27-L/CD70 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T67805-Ab-1/ GM-Tg-hg-T67805-Ab-2 | Anti-Human CD27-L/CD70 monoclonal antibody | Human |
| GM-Tg-rg-T67805-Ab-1/ GM-Tg-rg-T67805-Ab-2 | Anti-Rat CD27-L/CD70 monoclonal antibody | Rat |
| GM-Tg-mg-T67805-Ab-1/ GM-Tg-mg-T67805-Ab-2 | Anti-Mouse CD27-L/CD70 monoclonal antibody | Mouse |
| GM-Tg-cynog-T67805-Ab-1/ GM-Tg-cynog-T67805-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CD27-L/CD70 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T67805-Ab-1/ GM-Tg-felg-T67805-Ab-2 | Anti-Feline CD27-L/CD70 monoclonal antibody | Feline |
| GM-Tg-cang-T67805-Ab-1/ GM-Tg-cang-T67805-Ab-2 | Anti-Canine CD27-L/CD70 monoclonal antibody | Canine |
| GM-Tg-bovg-T67805-Ab-1/ GM-Tg-bovg-T67805-Ab-2 | Anti-Bovine CD27-L/CD70 monoclonal antibody | Bovine |
| GM-Tg-equg-T67805-Ab-1/ GM-Tg-equg-T67805-Ab-2 | Anti-Equine CD27-L/CD70 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T67805-Ab-1/ GM-Tg-hg-T67805-Ab-2; GM-Tg-rg-T67805-Ab-1/ GM-Tg-rg-T67805-Ab-2; GM-Tg-mg-T67805-Ab-1/ GM-Tg-mg-T67805-Ab-2; GM-Tg-cynog-T67805-Ab-1/ GM-Tg-cynog-T67805-Ab-2; GM-Tg-felg-T67805-Ab-1/ GM-Tg-felg-T67805-Ab-2; GM-Tg-cang-T67805-Ab-1/ GM-Tg-cang-T67805-Ab-2; GM-Tg-bovg-T67805-Ab-1/ GM-Tg-bovg-T67805-Ab-2; GM-Tg-equg-T67805-Ab-1/ GM-Tg-equg-T67805-Ab-2 |
| Products Name | Anti-CD27-L/CD70 monoclonal antibody |
| Format | mab |
| Target Name | CD27-L |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CD27-L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-630 | Pre-Made Vorsetuzumab biosimilar, Whole mAb ADC, Anti-CD70/CD27-L Antibody: Anti-CD27L/LPFS3/CD27LG/TNFSF7/TNLG8A therapeutic antibody |
| Biosimilar | GMP-Bios-ab-127 | Pre-Made Cusatuzumab biosimilar, Whole mAb, Anti-CD70/CD27-L Antibody: Anti-CD27L/LPFS3/CD27LG/TNFSF7/TNLG8A therapeutic antibody |
| Biosimilar | GMP-Bios-INN-1050 | Pre-Made Vorsetuzumab Mafodotin Biosimilar, Whole Mab Adc, Anti-CD70/CD27-L Antibody: Anti-CD27LG/LPFS3/TNFSF7/TNLG8A therapeutic antibody Drug Conjugate |
| Target Antigen | Products Developing | Multi-species CD70/ CD27-L/ CD27L VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T67805-Ag-1 | CD70 antigen (CD70) protein |
| ORF Viral Vector | vGMLP002733 | human CD70 Lentivirus particle |
| ORF Viral Vector | pGMLP002733 | human CD70 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000052 | mouse Cd70 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000052 | mouse Cd70 Lentivirus particle |
Target information
| Target ID | GM-T67805 |
| Target Name | CD27-L |
| Gene ID | 970,21948,301132,701080,485018,101087455,522074,100065854 |
| Gene Symbol and Synonyms | CD27-L,CD27L,CD27LG,CD70,LPFS3,TNFSF7,TNLG8A |
| Uniprot Accession | P32970 |
| Uniprot Entry Name | CD70_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000125726 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: CD27-L, gene name: CD70, also named as CD27-L, CD27L, CD27LG, TNFSF7, TNLG8A. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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