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Anti-ANGT/ AGT/ ANHU functional antibody
Anti-ANGT/ AGT/ ANHU functional antibody for cell culture, ELISA & in-vivo assay
Go to AGT/AGT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64485-Ab-1/ GM-Tg-hg-T64485-Ab-2 | Anti-Human AGT monoclonal antibody | Human |
| GM-Tg-rg-T64485-Ab-1/ GM-Tg-rg-T64485-Ab-2 | Anti-Rat AGT monoclonal antibody | Rat |
| GM-Tg-mg-T64485-Ab-1/ GM-Tg-mg-T64485-Ab-2 | Anti-Mouse AGT monoclonal antibody | Mouse |
| GM-Tg-cynog-T64485-Ab-1/ GM-Tg-cynog-T64485-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AGT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64485-Ab-1/ GM-Tg-felg-T64485-Ab-2 | Anti-Feline AGT monoclonal antibody | Feline |
| GM-Tg-cang-T64485-Ab-1/ GM-Tg-cang-T64485-Ab-2 | Anti-Canine AGT monoclonal antibody | Canine |
| GM-Tg-bovg-T64485-Ab-1/ GM-Tg-bovg-T64485-Ab-2 | Anti-Bovine AGT monoclonal antibody | Bovine |
| GM-Tg-equg-T64485-Ab-1/ GM-Tg-equg-T64485-Ab-2 | Anti-Equine AGT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64485-Ab-1/ GM-Tg-hg-T64485-Ab-2; GM-Tg-rg-T64485-Ab-1/ GM-Tg-rg-T64485-Ab-2; GM-Tg-mg-T64485-Ab-1/ GM-Tg-mg-T64485-Ab-2; GM-Tg-cynog-T64485-Ab-1/ GM-Tg-cynog-T64485-Ab-2; GM-Tg-felg-T64485-Ab-1/ GM-Tg-felg-T64485-Ab-2; GM-Tg-cang-T64485-Ab-1/ GM-Tg-cang-T64485-Ab-2; GM-Tg-bovg-T64485-Ab-1/ GM-Tg-bovg-T64485-Ab-2; GM-Tg-equg-T64485-Ab-1/ GM-Tg-equg-T64485-Ab-2 |
| Products Name | Anti-AGT monoclonal antibody |
| Format | mab |
| Target Name | AGT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AGT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T64485-Ag-1 | Recombinant multi-species ANGT/ AGT/ ANHU protein |
| ORF Viral Vector | pGMLPm002076 | mouse Agt Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002076 | mouse Agt Lentivirus particle |
Target information
| Target ID | GM-T64485 |
| Target Name | AGT |
| Gene ID | 183,11606,24179,714203,403783,101093714,527114,100065526 |
| Gene Symbol and Synonyms | AGT,Ang,AngI,AngII,ANHU,ANRT,Aogen,hFLT1,PAT,SERPINA8 |
| Uniprot Accession | P01019,P01015,P01017,P01016 |
| Uniprot Entry Name | ANGT_HUMAN,ANGT_RAT,ANGT_BOVIN,ANGT_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | Chronic Kidney Disease, IgA glomerulonephritis |
| Gene Ensembl | ENSG00000135744 |
| Target Classification | N/A |
The target: AGT, gene name: AGT, also named as ANHU, SERPINA8, hFLT1. The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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