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Anti-TNFL6/ CD178/ FASLG monoclonal antibody
Anti-TNFL6/ CD178/ FASLG antibody for FACS & in-vivo assay
Go to CD178/FASLG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64245-Ab-1/ GM-Tg-hg-T64245-Ab-2 | Anti-Human CD178/FASLG monoclonal antibody | Human |
| GM-Tg-rg-T64245-Ab-1/ GM-Tg-rg-T64245-Ab-2 | Anti-Rat CD178/FASLG monoclonal antibody | Rat |
| GM-Tg-mg-T64245-Ab-1/ GM-Tg-mg-T64245-Ab-2 | Anti-Mouse CD178/FASLG monoclonal antibody | Mouse |
| GM-Tg-cynog-T64245-Ab-1/ GM-Tg-cynog-T64245-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CD178/FASLG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64245-Ab-1/ GM-Tg-felg-T64245-Ab-2 | Anti-Feline CD178/FASLG monoclonal antibody | Feline |
| GM-Tg-cang-T64245-Ab-1/ GM-Tg-cang-T64245-Ab-2 | Anti-Canine CD178/FASLG monoclonal antibody | Canine |
| GM-Tg-bovg-T64245-Ab-1/ GM-Tg-bovg-T64245-Ab-2 | Anti-Bovine CD178/FASLG monoclonal antibody | Bovine |
| GM-Tg-equg-T64245-Ab-1/ GM-Tg-equg-T64245-Ab-2 | Anti-Equine CD178/FASLG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64245-Ab-1/ GM-Tg-hg-T64245-Ab-2; GM-Tg-rg-T64245-Ab-1/ GM-Tg-rg-T64245-Ab-2; GM-Tg-mg-T64245-Ab-1/ GM-Tg-mg-T64245-Ab-2; GM-Tg-cynog-T64245-Ab-1/ GM-Tg-cynog-T64245-Ab-2; GM-Tg-felg-T64245-Ab-1/ GM-Tg-felg-T64245-Ab-2; GM-Tg-cang-T64245-Ab-1/ GM-Tg-cang-T64245-Ab-2; GM-Tg-bovg-T64245-Ab-1/ GM-Tg-bovg-T64245-Ab-2; GM-Tg-equg-T64245-Ab-1/ GM-Tg-equg-T64245-Ab-2 |
| Products Name | Anti-CD178/FASLG monoclonal antibody |
| Format | mab |
| Target Name | CD178 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CD178 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-741 | Pre-Made Asunercept Biosimilar, Fusion Protein targeting FASLG/CD178 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting ALPS1B/APT1LG1/APTL/CD95-L/CD95L/FASL/TNFSF6/TNLG1A |
| Target Antigen | Products Developing | Multi-species TNFL6/ CD178/ FASLG VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T64245-Ag-1 | Fas ligand (TNF superfamily, member 6) (FASL) protein |
| ORF Viral Vector | pGMLP000545 | human FASLG Lentivirus plasmid |
| ORF Viral Vector | vGMAP000429 | Human FASLG Adenovirus particle |
| ORF Viral Vector | vGMLP000545 | human FASLG Lentivirus particle |
| ORF Viral Vector | pGMAP000429 | Human FASLG Adenovirus plasmid |
| ORF Viral Vector | pGMLV000739 | Norway rat Faslg Lentivirus plasmid |
| ORF Viral Vector | vGMLV000739 | Norway rat Faslg Lentivirus particle |
| ORF Viral Vector | pGMLPm004515 | mouse Fasl Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004515 | mouse Fasl Lentivirus particle |
Target information
| Target ID | GM-T64245 |
| Target Name | CD178 |
| Gene ID | 356,14103,25385,574159,442968,493945,407111,100052326 |
| Gene Symbol and Synonyms | ALPS1B,APT1LG1,APTL,CD178,CD95-L,CD95L,Fas-L,FASL,FASLG,gld,TNFSF6,TNLG1A |
| Uniprot Accession | P48023,P36940,P63307,Q861W5 |
| Uniprot Entry Name | TNFL6_HUMAN,TNFL6_MACMU,TNFL6_RAT,TNFL6_FELCA |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000117560 |
| Target Classification | N/A |
The target: CD178, gene name: FASLG, also named as ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A. This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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