Anti-VGFR1/ FLT-1/ FLT1 monoclonal antibody

Anti-VGFR1/ FLT-1/ FLT1 antibody for FACS & in-vivo assay

Target products collectionGo to FLT-1/FLT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T63966-Ab-1/ GM-Tg-hg-T63966-Ab-2Anti-Human FLT-1/FLT1 monoclonal antibodyHuman
GM-Tg-rg-T63966-Ab-1/ GM-Tg-rg-T63966-Ab-2Anti-Rat FLT-1/FLT1 monoclonal antibodyRat
GM-Tg-mg-T63966-Ab-1/ GM-Tg-mg-T63966-Ab-2Anti-Mouse FLT-1/FLT1 monoclonal antibodyMouse
GM-Tg-cynog-T63966-Ab-1/ GM-Tg-cynog-T63966-Ab-2Anti-Cynomolgus/ Rhesus macaque FLT-1/FLT1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T63966-Ab-1/ GM-Tg-felg-T63966-Ab-2Anti-Feline FLT-1/FLT1 monoclonal antibodyFeline
GM-Tg-cang-T63966-Ab-1/ GM-Tg-cang-T63966-Ab-2Anti-Canine FLT-1/FLT1 monoclonal antibodyCanine
GM-Tg-bovg-T63966-Ab-1/ GM-Tg-bovg-T63966-Ab-2Anti-Bovine FLT-1/FLT1 monoclonal antibodyBovine
GM-Tg-equg-T63966-Ab-1/ GM-Tg-equg-T63966-Ab-2Anti-Equine FLT-1/FLT1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T63966-Ab-1/ GM-Tg-hg-T63966-Ab-2; GM-Tg-rg-T63966-Ab-1/ GM-Tg-rg-T63966-Ab-2;
GM-Tg-mg-T63966-Ab-1/ GM-Tg-mg-T63966-Ab-2; GM-Tg-cynog-T63966-Ab-1/ GM-Tg-cynog-T63966-Ab-2;
GM-Tg-felg-T63966-Ab-1/ GM-Tg-felg-T63966-Ab-2; GM-Tg-cang-T63966-Ab-1/ GM-Tg-cang-T63966-Ab-2;
GM-Tg-bovg-T63966-Ab-1/ GM-Tg-bovg-T63966-Ab-2; GM-Tg-equg-T63966-Ab-1/ GM-Tg-equg-T63966-Ab-2
Products NameAnti-FLT-1/FLT1 monoclonal antibody
Formatmab
Target NameFLT-1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FLT-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-259Pre-Made Icrucumab biosimilar, Whole mAb, Anti-FLT1/FLT-1 Antibody: Anti-VEGFR-1/VEGFR1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species VGFR1/ FLT-1/ FLT1 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T63966-Ag-1fms-related tyrosine kinase 1 (FLT1) protein
    ORF Viral VectorvGMLV000309human FLT1 Lentivirus particle
    ORF Viral VectorvGMAAV000141human FLT1 AAV particle
    ORF Viral VectorpGMLV000309human FLT1 Lentivirus plasmid
    ORF Viral VectorpGMAD000439human FLT1 Adenovirus plasmid
    ORF Viral VectorvGMAD000439human FLT1 Adenovirus particle
    ORF Viral VectorpGMAAV000141human FLT1 AAV plasmid
    ORF Viral VectorpGMAD000232mouse Flt1 Adenovirus plasmid
    ORF Viral VectorpGMAD000457house mouse Flt1 Adenovirus plasmid
    ORF Viral VectorpGMAD000616house mouse Flt1 Adenovirus plasmid
    ORF Viral VectorvGMAD000232mouse Flt1 Adenovirus particle
    ORF Viral VectorvGMAD000457house mouse Flt1 Adenovirus particle
    ORF Viral VectorvGMAD000616house mouse Flt1 Adenovirus particle


    Target information

    Target IDGM-T63966
    Target NameFLT-1
    Gene ID2321,14254,54251,574133,403727,101088292,503620,100033957
    Gene Symbol and SynonymsFLT,FLT-1,FLT1,sFlt1,VEGFR-1,VEGFR1
    Uniprot AccessionP17948,P53767
    Uniprot Entry NameVGFR1_HUMAN,VGFR1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000102755
    Target ClassificationCheckpoint-Immuno Oncology, Kinase

    The target: FLT-1, gene name: FLT1, also named as FLT, FLT-1, VEGFR-1, VEGFR1. This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.