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Anti-IL25/ IL17E functional antibody
Anti-IL25/ IL17E functional antibody for cell culture, ELISA & in-vivo assay
Go to IL25/IL25 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T62241-Ab-1/ GM-Tg-hg-T62241-Ab-2 | Anti-Human IL25 monoclonal antibody | Human |
| GM-Tg-rg-T62241-Ab-1/ GM-Tg-rg-T62241-Ab-2 | Anti-Rat IL25 monoclonal antibody | Rat |
| GM-Tg-mg-T62241-Ab-1/ GM-Tg-mg-T62241-Ab-2 | Anti-Mouse IL25 monoclonal antibody | Mouse |
| GM-Tg-cynog-T62241-Ab-1/ GM-Tg-cynog-T62241-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL25 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T62241-Ab-1/ GM-Tg-felg-T62241-Ab-2 | Anti-Feline IL25 monoclonal antibody | Feline |
| GM-Tg-cang-T62241-Ab-1/ GM-Tg-cang-T62241-Ab-2 | Anti-Canine IL25 monoclonal antibody | Canine |
| GM-Tg-bovg-T62241-Ab-1/ GM-Tg-bovg-T62241-Ab-2 | Anti-Bovine IL25 monoclonal antibody | Bovine |
| GM-Tg-equg-T62241-Ab-1/ GM-Tg-equg-T62241-Ab-2 | Anti-Equine IL25 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T62241-Ab-1/ GM-Tg-hg-T62241-Ab-2; GM-Tg-rg-T62241-Ab-1/ GM-Tg-rg-T62241-Ab-2; GM-Tg-mg-T62241-Ab-1/ GM-Tg-mg-T62241-Ab-2; GM-Tg-cynog-T62241-Ab-1/ GM-Tg-cynog-T62241-Ab-2; GM-Tg-felg-T62241-Ab-1/ GM-Tg-felg-T62241-Ab-2; GM-Tg-cang-T62241-Ab-1/ GM-Tg-cang-T62241-Ab-2; GM-Tg-bovg-T62241-Ab-1/ GM-Tg-bovg-T62241-Ab-2; GM-Tg-equg-T62241-Ab-1/ GM-Tg-equg-T62241-Ab-2 |
| Products Name | Anti-IL25 monoclonal antibody |
| Format | mab |
| Target Name | IL25 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL25 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T62241-Ag-1 | Recombinant multi-species IL25/ IL17E protein |
| Cytokine | GM-Tg-g-T62241-Ag-1 | Interleukin 25 (IL25) protein |
| ORF Viral Vector | pGMAP000371 | Human IL25 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000371 | Human IL25 Adenovirus particle |
Target information
| Target ID | GM-T62241 |
| Target Name | IL25 |
| Gene ID | 64806,140806,501996,713943,480252,101095746,526816,111768801 |
| Gene Symbol and Synonyms | IL-17e,IL-25,IL17E,IL25,RGD1561632 |
| Uniprot Accession | Q9H293 |
| Uniprot Entry Name | IL25_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000166090 |
| Target Classification | N/A |
The target: IL25, gene name: IL25, also named as IL17E. The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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