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Anti-CNTFR monoclonal antibody
Anti-CNTFR antibody for FACS & in-vivo assay
Go to CNTFR/CNTFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T61033-Ab-1/ GM-Tg-hg-T61033-Ab-2 | Anti-Human CNTFR monoclonal antibody | Human |
| GM-Tg-rg-T61033-Ab-1/ GM-Tg-rg-T61033-Ab-2 | Anti-Rat CNTFR monoclonal antibody | Rat |
| GM-Tg-mg-T61033-Ab-1/ GM-Tg-mg-T61033-Ab-2 | Anti-Mouse CNTFR monoclonal antibody | Mouse |
| GM-Tg-cynog-T61033-Ab-1/ GM-Tg-cynog-T61033-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CNTFR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T61033-Ab-1/ GM-Tg-felg-T61033-Ab-2 | Anti-Feline CNTFR monoclonal antibody | Feline |
| GM-Tg-cang-T61033-Ab-1/ GM-Tg-cang-T61033-Ab-2 | Anti-Canine CNTFR monoclonal antibody | Canine |
| GM-Tg-bovg-T61033-Ab-1/ GM-Tg-bovg-T61033-Ab-2 | Anti-Bovine CNTFR monoclonal antibody | Bovine |
| GM-Tg-equg-T61033-Ab-1/ GM-Tg-equg-T61033-Ab-2 | Anti-Equine CNTFR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T61033-Ab-1/ GM-Tg-hg-T61033-Ab-2; GM-Tg-rg-T61033-Ab-1/ GM-Tg-rg-T61033-Ab-2; GM-Tg-mg-T61033-Ab-1/ GM-Tg-mg-T61033-Ab-2; GM-Tg-cynog-T61033-Ab-1/ GM-Tg-cynog-T61033-Ab-2; GM-Tg-felg-T61033-Ab-1/ GM-Tg-felg-T61033-Ab-2; GM-Tg-cang-T61033-Ab-1/ GM-Tg-cang-T61033-Ab-2; GM-Tg-bovg-T61033-Ab-1/ GM-Tg-bovg-T61033-Ab-2; GM-Tg-equg-T61033-Ab-1/ GM-Tg-equg-T61033-Ab-2 |
| Products Name | Anti-CNTFR monoclonal antibody |
| Format | mab |
| Target Name | CNTFR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CNTFR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CNTFR VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T61033-Ag-1 | ciliary neurotrophic factor receptor (CNTFR) protein |
| ORF Viral Vector | vGMLP004075 | human CNTFR Lentivirus particle |
| ORF Viral Vector | pGMLP004075 | human CNTFR Lentivirus plasmid |
Target information
| Target ID | GM-T61033 |
| Target Name | CNTFR |
| Gene ID | 1271,12804,313173,700959,442941,101083719,539548,100146590 |
| Gene Symbol and Synonyms | CNTFR,CNTFR-alpha,Cntfralpha |
| Uniprot Accession | P26992,Q08406,Q71DR4 |
| Uniprot Entry Name | CNTFR_HUMAN,CNTFR_RAT,CNTFR_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000122756 |
| Target Classification | N/A |
The target: CNTFR, gene name: CNTFR, also named as . This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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