Anti-SOST/ CDD/ DAND61 functional antibody

Anti-SOST/ CDD/ DAND61 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to SOST/SOST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T60724-Ab-1/ GM-Tg-hg-T60724-Ab-2Anti-Human SOST monoclonal antibodyHuman
GM-Tg-rg-T60724-Ab-1/ GM-Tg-rg-T60724-Ab-2Anti-Rat SOST monoclonal antibodyRat
GM-Tg-mg-T60724-Ab-1/ GM-Tg-mg-T60724-Ab-2Anti-Mouse SOST monoclonal antibodyMouse
GM-Tg-cynog-T60724-Ab-1/ GM-Tg-cynog-T60724-Ab-2Anti-Cynomolgus/ Rhesus macaque SOST monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T60724-Ab-1/ GM-Tg-felg-T60724-Ab-2Anti-Feline SOST monoclonal antibodyFeline
GM-Tg-cang-T60724-Ab-1/ GM-Tg-cang-T60724-Ab-2Anti-Canine SOST monoclonal antibodyCanine
GM-Tg-bovg-T60724-Ab-1/ GM-Tg-bovg-T60724-Ab-2Anti-Bovine SOST monoclonal antibodyBovine
GM-Tg-equg-T60724-Ab-1/ GM-Tg-equg-T60724-Ab-2Anti-Equine SOST monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T60724-Ab-1/ GM-Tg-hg-T60724-Ab-2; GM-Tg-rg-T60724-Ab-1/ GM-Tg-rg-T60724-Ab-2;
GM-Tg-mg-T60724-Ab-1/ GM-Tg-mg-T60724-Ab-2; GM-Tg-cynog-T60724-Ab-1/ GM-Tg-cynog-T60724-Ab-2;
GM-Tg-felg-T60724-Ab-1/ GM-Tg-felg-T60724-Ab-2; GM-Tg-cang-T60724-Ab-1/ GM-Tg-cang-T60724-Ab-2;
GM-Tg-bovg-T60724-Ab-1/ GM-Tg-bovg-T60724-Ab-2; GM-Tg-equg-T60724-Ab-1/ GM-Tg-equg-T60724-Ab-2
Products NameAnti-SOST monoclonal antibody
Formatmab
Target NameSOST
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SOST benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-493Pre-Made Romosozumab biosimilar, Whole mAb, Anti-SOST Antibody: Anti-CDD/DAND6/VBCH therapeutic antibody
    BiosimilarGMP-Bios-ab-076Pre-Made Blosozumab biosimilar, Whole mAb, Anti-SOST Antibody: Anti-CDD/DAND6/VBCH therapeutic antibody
    BiosimilarGMP-Bios-ab-517Pre-Made Setrusumab biosimilar, Whole mAb, Anti-SOST Antibody: Anti-CDD/DAND6/VBCH therapeutic antibody
    Target AntigenGM-Tg-g-T60724-Ag-1Recombinant multi-species SOST/ CDD/ DAND61 protein
    ORF Viral VectorvGMLV000548human SOST Lentivirus particle
    ORF Viral VectorpGMLV000058human SOST Lentivirus plasmid
    ORF Viral VectorvGMLV000058human SOST Lentivirus particle
    ORF Viral VectorvGMLP005026human SOST Lentivirus particle
    ORF Viral VectorpGMLP005026human SOST Lentivirus plasmid
    ORF Viral VectorpGMLV000548human SOST Lentivirus plasmid
    ORF Viral VectorpGMLV000563house mouse sost Lentivirus plasmid
    ORF Viral VectorpGMLPm001306mouse Sost Lentivirus plasmid
    ORF Viral VectorvGMLV000563house mouse sost Lentivirus particle
    ORF Viral VectorvGMLPm001306mouse Sost Lentivirus particle


    Target information

    Target IDGM-T60724
    Target NameSOST
    Gene ID50964,74499,80722,713617,490948,101083725,282880,100065060
    Gene Symbol and Synonyms5430411E23Rik,CDD,DAND6,SOST,SOST1,VBCH
    Uniprot AccessionQ9BQB4,Q99P67,Q9BG79
    Uniprot Entry NameSOST_HUMAN,SOST_RAT,SOST_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, INN Index
    DiseaseBreast Cancer
    Gene EnsemblENSG00000167941
    Target ClassificationN/A

    The target: SOST, gene name: SOST, also named as CDD, DAND61, VBCH, SOST. Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.