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Anti-BMPR2/ BMPR-II/ BMPR3 monoclonal antibody
Anti-BMPR2/ BMPR-II/ BMPR3 antibody for FACS & in-vivo assay
Go to BMPR2/BMPR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T60213-Ab-1/ GM-Tg-hg-T60213-Ab-2 | Anti-Human BMPR2 monoclonal antibody | Human |
| GM-Tg-rg-T60213-Ab-1/ GM-Tg-rg-T60213-Ab-2 | Anti-Rat BMPR2 monoclonal antibody | Rat |
| GM-Tg-mg-T60213-Ab-1/ GM-Tg-mg-T60213-Ab-2 | Anti-Mouse BMPR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T60213-Ab-1/ GM-Tg-cynog-T60213-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BMPR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T60213-Ab-1/ GM-Tg-felg-T60213-Ab-2 | Anti-Feline BMPR2 monoclonal antibody | Feline |
| GM-Tg-cang-T60213-Ab-1/ GM-Tg-cang-T60213-Ab-2 | Anti-Canine BMPR2 monoclonal antibody | Canine |
| GM-Tg-bovg-T60213-Ab-1/ GM-Tg-bovg-T60213-Ab-2 | Anti-Bovine BMPR2 monoclonal antibody | Bovine |
| GM-Tg-equg-T60213-Ab-1/ GM-Tg-equg-T60213-Ab-2 | Anti-Equine BMPR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T60213-Ab-1/ GM-Tg-hg-T60213-Ab-2; GM-Tg-rg-T60213-Ab-1/ GM-Tg-rg-T60213-Ab-2; GM-Tg-mg-T60213-Ab-1/ GM-Tg-mg-T60213-Ab-2; GM-Tg-cynog-T60213-Ab-1/ GM-Tg-cynog-T60213-Ab-2; GM-Tg-felg-T60213-Ab-1/ GM-Tg-felg-T60213-Ab-2; GM-Tg-cang-T60213-Ab-1/ GM-Tg-cang-T60213-Ab-2; GM-Tg-bovg-T60213-Ab-1/ GM-Tg-bovg-T60213-Ab-2; GM-Tg-equg-T60213-Ab-1/ GM-Tg-equg-T60213-Ab-2 |
| Products Name | Anti-BMPR2 monoclonal antibody |
| Format | mab |
| Target Name | BMPR2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BMPR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species BMPR2/ BMPR-II/ BMPR3 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T60213-Ag-1 | bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2) protein |
Target information
| Target ID | GM-T60213 |
| Target Name | BMPR2 |
| Gene ID | 659,12168,140590,704088,478875,101096338,407127,100067195 |
| Gene Symbol and Synonyms | 2610024H22Rik,BMP-2,BMPR-2,BMPR-II,BMPR2,BMPR3,BMPRII,BMR2,BRK-3,Gm20272,POVD1,PPH1,T-ALK |
| Uniprot Accession | Q13873 |
| Uniprot Entry Name | BMPR2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000204217 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: BMPR2, gene name: BMPR2, also named as BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK. This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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