Anti-B2MG/ B2M/ IMD43 monoclonal antibody

Anti-B2MG/ B2M/ IMD43 antibody for FACS & in-vivo assay

Target products collectionGo to B2M/B2M products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T58080-Ab-1/ GM-Tg-hg-T58080-Ab-2Anti-Human B2M monoclonal antibodyHuman
GM-Tg-rg-T58080-Ab-1/ GM-Tg-rg-T58080-Ab-2Anti-Rat B2M monoclonal antibodyRat
GM-Tg-mg-T58080-Ab-1/ GM-Tg-mg-T58080-Ab-2Anti-Mouse B2M monoclonal antibodyMouse
GM-Tg-cynog-T58080-Ab-1/ GM-Tg-cynog-T58080-Ab-2Anti-Cynomolgus/ Rhesus macaque B2M monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T58080-Ab-1/ GM-Tg-felg-T58080-Ab-2Anti-Feline B2M monoclonal antibodyFeline
GM-Tg-cang-T58080-Ab-1/ GM-Tg-cang-T58080-Ab-2Anti-Canine B2M monoclonal antibodyCanine
GM-Tg-bovg-T58080-Ab-1/ GM-Tg-bovg-T58080-Ab-2Anti-Bovine B2M monoclonal antibodyBovine
GM-Tg-equg-T58080-Ab-1/ GM-Tg-equg-T58080-Ab-2Anti-Equine B2M monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T58080-Ab-1/ GM-Tg-hg-T58080-Ab-2; GM-Tg-rg-T58080-Ab-1/ GM-Tg-rg-T58080-Ab-2;
GM-Tg-mg-T58080-Ab-1/ GM-Tg-mg-T58080-Ab-2; GM-Tg-cynog-T58080-Ab-1/ GM-Tg-cynog-T58080-Ab-2;
GM-Tg-felg-T58080-Ab-1/ GM-Tg-felg-T58080-Ab-2; GM-Tg-cang-T58080-Ab-1/ GM-Tg-cang-T58080-Ab-2;
GM-Tg-bovg-T58080-Ab-1/ GM-Tg-bovg-T58080-Ab-2; GM-Tg-equg-T58080-Ab-1/ GM-Tg-equg-T58080-Ab-2
Products NameAnti-B2M monoclonal antibody
Formatmab
Target NameB2M
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-B2M benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species B2MG/ B2M/ IMD43 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAP000411Human B2M Adenovirus plasmid
    ORF Viral VectorvGMLP000539human B2M Lentivirus particle
    ORF Viral VectorpGMLP000539human B2M Lentivirus plasmid
    ORF Viral VectorvGMAP000411Human B2M Adenovirus particle
    ORF Viral VectorpGMLPm000028mouse B2m Lentivirus plasmid
    ORF Viral VectorvGMLPm000028mouse B2m Lentivirus particle


    Target information

    Target IDGM-T58080
    Target NameB2M
    Gene ID567,12010,24223,712428,100855741,494145,100034203
    Gene Symbol and SynonymsB2M,beta2-m,beta2m,IMD43,Ly-m11
    Uniprot AccessionP61769,P07151,Q6V7J5,P19341,Q5MGS7,P30441
    Uniprot Entry NameB2MG_HUMAN,B2MG_MACMU,B2MG_RAT,B2MG_FELCA,B2MG_CANLF,B2MG_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Diagnostics Biomarker
    DiseaseOvary Cancer, Urinary tract obstruction, Malignant neoplasm of prostate, Congenital occlusion of ureteropelvic junction, Acute kidney failure, Asphyxia neonatorum, Autosomal Dominant Polycystic Kidney Disease, Balkan nephropathy, Bronchopulmonary Dysplasia, Dent disease, Kidney transplant rejection, lymphomas, Malignant neoplasm of colon, Nephropathy induced by other drugs, medicaments and biological substances, Nephrotic syndrome, Proteinuria, Renal fibrosis, Peripheral T-cell lymphomas (PTCL)
    Gene EnsemblENSG00000166710
    Target ClassificationN/A

    The target: B2M, gene name: B2M, also named as IMD43. This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.