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Anti-TNFAIP3 monoclonal antibody
Pre-made anti-TNFAIP3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TNFAIP3/TNFAIP3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T56474-Ab-1/ GM-Tg-hg-T56474-Ab-2 | Anti-Human TNFAIP3 monoclonal antibody | Human |
| GM-Tg-rg-T56474-Ab-1/ GM-Tg-rg-T56474-Ab-2 | Anti-Rat TNFAIP3 monoclonal antibody | Rat |
| GM-Tg-mg-T56474-Ab-1/ GM-Tg-mg-T56474-Ab-2 | Anti-Mouse TNFAIP3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T56474-Ab-1/ GM-Tg-cynog-T56474-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFAIP3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T56474-Ab-1/ GM-Tg-felg-T56474-Ab-2 | Anti-Feline TNFAIP3 monoclonal antibody | Feline |
| GM-Tg-cang-T56474-Ab-1/ GM-Tg-cang-T56474-Ab-2 | Anti-Canine TNFAIP3 monoclonal antibody | Canine |
| GM-Tg-bovg-T56474-Ab-1/ GM-Tg-bovg-T56474-Ab-2 | Anti-Bovine TNFAIP3 monoclonal antibody | Bovine |
| GM-Tg-equg-T56474-Ab-1/ GM-Tg-equg-T56474-Ab-2 | Anti-Equine TNFAIP3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T56474-Ab-1/ GM-Tg-hg-T56474-Ab-2; GM-Tg-rg-T56474-Ab-1/ GM-Tg-rg-T56474-Ab-2; GM-Tg-mg-T56474-Ab-1/ GM-Tg-mg-T56474-Ab-2; GM-Tg-cynog-T56474-Ab-1/ GM-Tg-cynog-T56474-Ab-2; GM-Tg-felg-T56474-Ab-1/ GM-Tg-felg-T56474-Ab-2; GM-Tg-cang-T56474-Ab-1/ GM-Tg-cang-T56474-Ab-2; GM-Tg-bovg-T56474-Ab-1/ GM-Tg-bovg-T56474-Ab-2; GM-Tg-equg-T56474-Ab-1/ GM-Tg-equg-T56474-Ab-2 |
| Products Name | Anti-TNFAIP3 monoclonal antibody |
| Format | mab |
| Target Name | TNFAIP3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TNFAIP3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T56474-Ag-1 | Recombinant multi-species TNAP3/ TNFAIP3/ A20 protein |
| Cytokine | GM-Tg-g-T56474-Ag-1 | tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) protein |
| ORF Viral Vector | vGMLV000596 | human TNFAIP3 Lentivirus particle |
| ORF Viral Vector | pGMLV000596 | human TNFAIP3 Lentivirus plasmid |
Target information
| Target ID | GM-T56474 |
| Target Name | TNFAIP3 |
| Gene ID | 7128,21929,683206,704130,484006,101083682,508105,100073197 |
| Gene Symbol and Synonyms | A20,AIFBL1,AISBL,OTUD7C,TNFA1P2,TNFAIP3,Tnfip3 |
| Uniprot Accession | P21580 |
| Uniprot Entry Name | TNAP3_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | IgA glomerulonephritis |
| Gene Ensembl | ENSG00000118503 |
| Target Classification | N/A |
The target: TNFAIP3, gene name: TNFAIP3, also named as A20, AISBL, OTUD7C, TNFA1P2. This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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