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Anti-IL11/ AGIF/ IL-11 functional antibody
Anti-IL11/ AGIF/ IL-11 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL11/IL11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T56308-Ab-1/ GM-Tg-hg-T56308-Ab-2 | Anti-Human IL11 monoclonal antibody | Human |
| GM-Tg-rg-T56308-Ab-1/ GM-Tg-rg-T56308-Ab-2 | Anti-Rat IL11 monoclonal antibody | Rat |
| GM-Tg-mg-T56308-Ab-1/ GM-Tg-mg-T56308-Ab-2 | Anti-Mouse IL11 monoclonal antibody | Mouse |
| GM-Tg-cynog-T56308-Ab-1/ GM-Tg-cynog-T56308-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL11 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T56308-Ab-1/ GM-Tg-felg-T56308-Ab-2 | Anti-Feline IL11 monoclonal antibody | Feline |
| GM-Tg-cang-T56308-Ab-1/ GM-Tg-cang-T56308-Ab-2 | Anti-Canine IL11 monoclonal antibody | Canine |
| GM-Tg-bovg-T56308-Ab-1/ GM-Tg-bovg-T56308-Ab-2 | Anti-Bovine IL11 monoclonal antibody | Bovine |
| GM-Tg-equg-T56308-Ab-1/ GM-Tg-equg-T56308-Ab-2 | Anti-Equine IL11 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T56308-Ab-1/ GM-Tg-hg-T56308-Ab-2; GM-Tg-rg-T56308-Ab-1/ GM-Tg-rg-T56308-Ab-2; GM-Tg-mg-T56308-Ab-1/ GM-Tg-mg-T56308-Ab-2; GM-Tg-cynog-T56308-Ab-1/ GM-Tg-cynog-T56308-Ab-2; GM-Tg-felg-T56308-Ab-1/ GM-Tg-felg-T56308-Ab-2; GM-Tg-cang-T56308-Ab-1/ GM-Tg-cang-T56308-Ab-2; GM-Tg-bovg-T56308-Ab-1/ GM-Tg-bovg-T56308-Ab-2; GM-Tg-equg-T56308-Ab-1/ GM-Tg-equg-T56308-Ab-2 |
| Products Name | Anti-IL11 monoclonal antibody |
| Format | mab |
| Target Name | IL11 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T56308-Ag-1 | Recombinant multi-species IL11/ AGIF/ IL-11 protein |
| Cytokine | GM-Tg-g-T56308-Ag-1 | interleukin 11 (IL11) protein |
| ORF Viral Vector | pGMLP003437 | human IL11 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003437 | human IL11 Lentivirus particle |
| ORF Viral Vector | pGMLPm000111 | mouse Il11 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000111 | mouse Il11 Lentivirus particle |
Target information
| Target ID | GM-T56308 |
| Target Name | IL11 |
| Gene ID | 3589,16156,171040,722817,611309,101085086,100337295,100056037 |
| Gene Symbol and Synonyms | AGIF,IL-11,IL11 |
| Uniprot Accession | P20809,Q99MF5 |
| Uniprot Entry Name | IL11_HUMAN,IL11_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000095752 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IL11, gene name: IL11, also named as AGIF, IL-11. The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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