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Anti-KDM6B monoclonal antibody
Pre-made anti-KDM6B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KDM6B/KDM6B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T56057-Ab-1/ GM-Tg-hg-T56057-Ab-2 | Anti-Human KDM6B monoclonal antibody | Human |
| GM-Tg-rg-T56057-Ab-1/ GM-Tg-rg-T56057-Ab-2 | Anti-Rat KDM6B monoclonal antibody | Rat |
| GM-Tg-mg-T56057-Ab-1/ GM-Tg-mg-T56057-Ab-2 | Anti-Mouse KDM6B monoclonal antibody | Mouse |
| GM-Tg-cynog-T56057-Ab-1/ GM-Tg-cynog-T56057-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KDM6B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T56057-Ab-1/ GM-Tg-felg-T56057-Ab-2 | Anti-Feline KDM6B monoclonal antibody | Feline |
| GM-Tg-cang-T56057-Ab-1/ GM-Tg-cang-T56057-Ab-2 | Anti-Canine KDM6B monoclonal antibody | Canine |
| GM-Tg-bovg-T56057-Ab-1/ GM-Tg-bovg-T56057-Ab-2 | Anti-Bovine KDM6B monoclonal antibody | Bovine |
| GM-Tg-equg-T56057-Ab-1/ GM-Tg-equg-T56057-Ab-2 | Anti-Equine KDM6B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T56057-Ab-1/ GM-Tg-hg-T56057-Ab-2; GM-Tg-rg-T56057-Ab-1/ GM-Tg-rg-T56057-Ab-2; GM-Tg-mg-T56057-Ab-1/ GM-Tg-mg-T56057-Ab-2; GM-Tg-cynog-T56057-Ab-1/ GM-Tg-cynog-T56057-Ab-2; GM-Tg-felg-T56057-Ab-1/ GM-Tg-felg-T56057-Ab-2; GM-Tg-cang-T56057-Ab-1/ GM-Tg-cang-T56057-Ab-2; GM-Tg-bovg-T56057-Ab-1/ GM-Tg-bovg-T56057-Ab-2; GM-Tg-equg-T56057-Ab-1/ GM-Tg-equg-T56057-Ab-2 |
| Products Name | Anti-KDM6B monoclonal antibody |
| Format | mab |
| Target Name | KDM6B |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KDM6B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T56057-Ag-1 | Recombinant multi-species KDM6B/ JMJD3 protein |
Target information
| Target ID | GM-T56057 |
| Target Name | KDM6B |
| Gene ID | 23135,216850,363630,716348,489481,101100010,100140276,100073033 |
| Gene Symbol and Synonyms | 1700064E03Rik,JMJD3,KDM6B,NEDCFSA |
| Uniprot Accession | O15054 |
| Uniprot Entry Name | KDM6B_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000132510 |
| Target Classification | N/A |
The target: KDM6B, gene name: KDM6B, also named as JMJD3. The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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