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Anti-ANFB/ BNP/ NPPB functional antibody
Anti-ANFB/ BNP/ NPPB functional antibody for cell culture, ELISA & in-vivo assay
Go to BNP/NPPB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T55302-Ab-1/ GM-Tg-hg-T55302-Ab-2 | Anti-Human BNP/NPPB monoclonal antibody | Human |
| GM-Tg-rg-T55302-Ab-1/ GM-Tg-rg-T55302-Ab-2 | Anti-Rat BNP/NPPB monoclonal antibody | Rat |
| GM-Tg-mg-T55302-Ab-1/ GM-Tg-mg-T55302-Ab-2 | Anti-Mouse BNP/NPPB monoclonal antibody | Mouse |
| GM-Tg-cynog-T55302-Ab-1/ GM-Tg-cynog-T55302-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BNP/NPPB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T55302-Ab-1/ GM-Tg-felg-T55302-Ab-2 | Anti-Feline BNP/NPPB monoclonal antibody | Feline |
| GM-Tg-cang-T55302-Ab-1/ GM-Tg-cang-T55302-Ab-2 | Anti-Canine BNP/NPPB monoclonal antibody | Canine |
| GM-Tg-bovg-T55302-Ab-1/ GM-Tg-bovg-T55302-Ab-2 | Anti-Bovine BNP/NPPB monoclonal antibody | Bovine |
| GM-Tg-equg-T55302-Ab-1/ GM-Tg-equg-T55302-Ab-2 | Anti-Equine BNP/NPPB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T55302-Ab-1/ GM-Tg-hg-T55302-Ab-2; GM-Tg-rg-T55302-Ab-1/ GM-Tg-rg-T55302-Ab-2; GM-Tg-mg-T55302-Ab-1/ GM-Tg-mg-T55302-Ab-2; GM-Tg-cynog-T55302-Ab-1/ GM-Tg-cynog-T55302-Ab-2; GM-Tg-felg-T55302-Ab-1/ GM-Tg-felg-T55302-Ab-2; GM-Tg-cang-T55302-Ab-1/ GM-Tg-cang-T55302-Ab-2; GM-Tg-bovg-T55302-Ab-1/ GM-Tg-bovg-T55302-Ab-2; GM-Tg-equg-T55302-Ab-1/ GM-Tg-equg-T55302-Ab-2 |
| Products Name | Anti-BNP/NPPB monoclonal antibody |
| Format | mab |
| Target Name | BNP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BNP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T55302-Ag-1 | Recombinant multi-species ANFB/ BNP/ NPPB protein |
| ORF Viral Vector | vGMAAV000027 | human NPPB AAV particle |
| ORF Viral Vector | pGMAAV000027 | human NPPB AAV plasmid |
| ORF Viral Vector | pGMLPm000014 | mouse Nppb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000014 | mouse Nppb Lentivirus particle |
Target information
| Target ID | GM-T55302 |
| Target Name | BNP |
| Gene ID | 4879,18158,25105,715053,487441,493764,508734,100056123 |
| Gene Symbol and Synonyms | BNF,BNP,Iso-ANP,NNX,NPPB |
| Uniprot Accession | P16860,P13205,P16859,P13204 |
| Uniprot Entry Name | ANFB_HUMAN,ANFB_RAT,ANFB_CANLF,ANFB_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000120937 |
| Target Classification | N/A |
The target: BNP, gene name: NPPB, also named as BNP. This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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