Human NPPB/BNPORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_002521.2)

SKU: pGMAAV000027
Size: 10 µg
Leading Time: 3-7 working days

Pre-made Human NPPB/BNP Adeno-associated virus expression plasmid (ITR-vector) for NPPB AAV packaging, NPPB AAV production.The purified Human NPPB/BNP AAV particle serves as an invaluable asset for in-depth in vivo NPPB studies, mechanism of action (MOA) research, and the evolution of NPPB-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV000027
Gene Name NPPB
Accession Number NM_002521.2
Gene ID 4879
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 405 bp
Gene Alias BNP
Fluorescent Reporter EGFP
Mammalian Cell Selection
Fusion Tag Null
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T55302-Ab Anti-ANFB/ BNP/ NPPB functional antibody
    Target Antigen GM-Tg-g-T55302-Ag BNP/NPPB protein
    ORF Viral Vector pGMAAV000027 Human NPPB Adeno-associate virus(AAV) plasmid
    ORF Viral Vector vGMAAV000027 Human NPPB Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-T55302
    Target Name BNP
    Gene ID 4879, 18158, 715053, 25105, 493764, 487441, 508734, 100056123
    Gene Symbol and Synonyms BNF,BNP,Iso-ANP,NNX,NPPB
    Uniprot Accession P16860
    Uniprot Entry Name ANFB_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Therapeutics Target, Diagnostics Biomarker
    Disease Not Available
    Gene Ensembl ENSG00000120937
    Target Classification Not Available

    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]



    About GMVC

    GDU

    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.