Anti-CXCR6/ BONZO/ CD186 monoclonal antibody

Anti-CXCR6/ BONZO/ CD186 antibody for FACS & in-vivo assay

Go to CXCR6/CXCR6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

MSDSCOADatasheet
Inquiry

Product information

Size： 1mg | 10mg | 100mg

Product Description

Reference

Data / case study

Click to get more Data / Case study about the product.

Associated products

Target information

The target: CXCR6, gene name: CXCR6, also named as BONZO, CD186, STRL33, TYMSTR. The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020].

About Gmab