Anti-PGFRA/ PDGFRA/ CD140A monoclonal antibody

Anti-PGFRA/ PDGFRA/ CD140A antibody for FACS & in-vivo assay

Target products collectionGo to PDGFRA/PDGFRA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T53524-Ab-1/ GM-Tg-hg-T53524-Ab-2Anti-Human PDGFRA monoclonal antibodyHuman
GM-Tg-rg-T53524-Ab-1/ GM-Tg-rg-T53524-Ab-2Anti-Rat PDGFRA monoclonal antibodyRat
GM-Tg-mg-T53524-Ab-1/ GM-Tg-mg-T53524-Ab-2Anti-Mouse PDGFRA monoclonal antibodyMouse
GM-Tg-cynog-T53524-Ab-1/ GM-Tg-cynog-T53524-Ab-2Anti-Cynomolgus/ Rhesus macaque PDGFRA monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T53524-Ab-1/ GM-Tg-felg-T53524-Ab-2Anti-Feline PDGFRA monoclonal antibodyFeline
GM-Tg-cang-T53524-Ab-1/ GM-Tg-cang-T53524-Ab-2Anti-Canine PDGFRA monoclonal antibodyCanine
GM-Tg-bovg-T53524-Ab-1/ GM-Tg-bovg-T53524-Ab-2Anti-Bovine PDGFRA monoclonal antibodyBovine
GM-Tg-equg-T53524-Ab-1/ GM-Tg-equg-T53524-Ab-2Anti-Equine PDGFRA monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T53524-Ab-1/ GM-Tg-hg-T53524-Ab-2; GM-Tg-rg-T53524-Ab-1/ GM-Tg-rg-T53524-Ab-2;
GM-Tg-mg-T53524-Ab-1/ GM-Tg-mg-T53524-Ab-2; GM-Tg-cynog-T53524-Ab-1/ GM-Tg-cynog-T53524-Ab-2;
GM-Tg-felg-T53524-Ab-1/ GM-Tg-felg-T53524-Ab-2; GM-Tg-cang-T53524-Ab-1/ GM-Tg-cang-T53524-Ab-2;
GM-Tg-bovg-T53524-Ab-1/ GM-Tg-bovg-T53524-Ab-2; GM-Tg-equg-T53524-Ab-1/ GM-Tg-equg-T53524-Ab-2
Products NameAnti-PDGFRA monoclonal antibody
Formatmab
Target NamePDGFRA
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PDGFRA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-393Pre-Made Olaratumab biosimilar, Whole mAb, Anti-PDGFRA Antibody: Anti-CD140A/PDGFR-2/PDGFR2 therapeutic antibody
    BiosimilarGMP-Bios-ab-590Pre-Made Tovetumab biosimilar, Whole mAb, Anti-PDGFRA Antibody: Anti-CD140A/PDGFR-2/PDGFR2 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species PGFRA/ PDGFRA/ CD140A VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T53524-Ag-1Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of theplatelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiat (PDGFRA) protein
    ORF Viral VectorvGMAP000154Human PDGFRA Adenovirus particle
    ORF Viral VectorpGMAP000154Human PDGFRA Adenovirus plasmid


    Target information

    Target IDGM-T53524
    Target NamePDGFRA
    Gene ID5156,18595,25267,697002,442860,101090765,282301,100059815
    Gene Symbol and SynonymsAPDGFR,CD140A,PDGFACE,PDGFR-2,PDGFR2,PDGFRA
    Uniprot AccessionP16234,P20786
    Uniprot Entry NamePGFRA_HUMAN,PGFRA_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseNon-Small Cell Lung Cancer
    Gene EnsemblENSG00000134853
    Target ClassificationN/A

    The target: PDGFRA, gene name: PDGFRA, also named as CD140A, PDGFR-2, PDGFR2. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.