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Anti-ATF-4 monoclonal antibody
Pre-made anti-ATF-4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ATF-4/ATF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53270-Ab-1/ GM-Tg-hg-T53270-Ab-2 | Anti-Human ATF-4/ATF4 monoclonal antibody | Human |
| GM-Tg-rg-T53270-Ab-1/ GM-Tg-rg-T53270-Ab-2 | Anti-Rat ATF-4/ATF4 monoclonal antibody | Rat |
| GM-Tg-mg-T53270-Ab-1/ GM-Tg-mg-T53270-Ab-2 | Anti-Mouse ATF-4/ATF4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T53270-Ab-1/ GM-Tg-cynog-T53270-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ATF-4/ATF4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53270-Ab-1/ GM-Tg-felg-T53270-Ab-2 | Anti-Feline ATF-4/ATF4 monoclonal antibody | Feline |
| GM-Tg-cang-T53270-Ab-1/ GM-Tg-cang-T53270-Ab-2 | Anti-Canine ATF-4/ATF4 monoclonal antibody | Canine |
| GM-Tg-bovg-T53270-Ab-1/ GM-Tg-bovg-T53270-Ab-2 | Anti-Bovine ATF-4/ATF4 monoclonal antibody | Bovine |
| GM-Tg-equg-T53270-Ab-1/ GM-Tg-equg-T53270-Ab-2 | Anti-Equine ATF-4/ATF4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53270-Ab-1/ GM-Tg-hg-T53270-Ab-2; GM-Tg-rg-T53270-Ab-1/ GM-Tg-rg-T53270-Ab-2; GM-Tg-mg-T53270-Ab-1/ GM-Tg-mg-T53270-Ab-2; GM-Tg-cynog-T53270-Ab-1/ GM-Tg-cynog-T53270-Ab-2; GM-Tg-felg-T53270-Ab-1/ GM-Tg-felg-T53270-Ab-2; GM-Tg-cang-T53270-Ab-1/ GM-Tg-cang-T53270-Ab-2; GM-Tg-bovg-T53270-Ab-1/ GM-Tg-bovg-T53270-Ab-2; GM-Tg-equg-T53270-Ab-1/ GM-Tg-equg-T53270-Ab-2 |
| Products Name | Anti-ATF-4/ATF4 monoclonal antibody |
| Format | mab |
| Target Name | ATF-4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ATF-4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T53270-Ag-1 | Recombinant multi-species ATF4/ ATF-4/ CREB-2 protein |
| ORF Viral Vector | vGMLV000321 | human ATF4 Lentivirus particle |
| ORF Viral Vector | pGMLV000496 | human ATF4 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000496 | human ATF4 Lentivirus particle |
| ORF Viral Vector | pGMLV000321 | human ATF4 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000646 | house mouse ATF4 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000180 | house mouse Atf4 AAV plasmid |
| ORF Viral Vector | pGMLPm004457 | mouse Atf4 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000646 | house mouse ATF4 Lentivirus particle |
| ORF Viral Vector | vGMAAV000180 | house mouse Atf4 AAV particle |
| ORF Viral Vector | vGMLPm004457 | mouse Atf4 Lentivirus particle |
Target information
| Target ID | GM-T53270 |
| Target Name | ATF-4 |
| Gene ID | 468,11911,79255,703965,474503,101084297,509107,100070334 |
| Gene Symbol and Synonyms | Atf-4,ATF4,C/ATF,CREB-2,CREB2,TAXREB67,TXREB |
| Uniprot Accession | P18848,Q9ES19,Q3ZCH6 |
| Uniprot Entry Name | ATF4_HUMAN,ATF4_RAT,ATF4_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000128272 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ATF-4, gene name: ATF4, also named as CREB-2, CREB2, TAXREB67, TXREB. This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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