Anti-GATA4 monoclonal antibody

Pre-made anti-GATA4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to GATA4/GATA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T51817-Ab-1/ GM-Tg-hg-T51817-Ab-2Anti-Human GATA4 monoclonal antibodyHuman
GM-Tg-rg-T51817-Ab-1/ GM-Tg-rg-T51817-Ab-2Anti-Rat GATA4 monoclonal antibodyRat
GM-Tg-mg-T51817-Ab-1/ GM-Tg-mg-T51817-Ab-2Anti-Mouse GATA4 monoclonal antibodyMouse
GM-Tg-cynog-T51817-Ab-1/ GM-Tg-cynog-T51817-Ab-2Anti-Cynomolgus/ Rhesus macaque GATA4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T51817-Ab-1/ GM-Tg-felg-T51817-Ab-2Anti-Feline GATA4 monoclonal antibodyFeline
GM-Tg-cang-T51817-Ab-1/ GM-Tg-cang-T51817-Ab-2Anti-Canine GATA4 monoclonal antibodyCanine
GM-Tg-bovg-T51817-Ab-1/ GM-Tg-bovg-T51817-Ab-2Anti-Bovine GATA4 monoclonal antibodyBovine
GM-Tg-equg-T51817-Ab-1/ GM-Tg-equg-T51817-Ab-2Anti-Equine GATA4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T51817-Ab-1/ GM-Tg-hg-T51817-Ab-2; GM-Tg-rg-T51817-Ab-1/ GM-Tg-rg-T51817-Ab-2;
GM-Tg-mg-T51817-Ab-1/ GM-Tg-mg-T51817-Ab-2; GM-Tg-cynog-T51817-Ab-1/ GM-Tg-cynog-T51817-Ab-2;
GM-Tg-felg-T51817-Ab-1/ GM-Tg-felg-T51817-Ab-2; GM-Tg-cang-T51817-Ab-1/ GM-Tg-cang-T51817-Ab-2;
GM-Tg-bovg-T51817-Ab-1/ GM-Tg-bovg-T51817-Ab-2; GM-Tg-equg-T51817-Ab-1/ GM-Tg-equg-T51817-Ab-2
Products NameAnti-GATA4 monoclonal antibody
Formatmab
Target NameGATA4
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-GATA4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T51817-Ag-1Recombinant multi-species GATA4/ ASD2/ TACHD protein
    ORF Viral VectorvGMAD000115human GATA4 Adenovirus particle
    ORF Viral VectorpGMAD000115human GATA4 Adenovirus plasmid
    ORF Viral VectorpGMLV000028rat Gata4 Lentivirus plasmid
    ORF Viral VectorpGMAAV000160rat Gata4 AAV plasmid
    ORF Viral VectorpGMAAV000209house mouse Gata4 AAV plasmid
    ORF Viral VectorpGMAAV000268house mouse Gata4 AAV plasmid
    ORF Viral VectorpGMLPm004341mouse Gata4 Lentivirus plasmid
    ORF Viral VectorvGMLV000028rat Gata4 Lentivirus particle
    ORF Viral VectorvGMAAV000160rat Gata4 AAV particle
    ORF Viral VectorvGMAAV000209house mouse Gata4 AAV particle
    ORF Viral VectorvGMAAV000268house mouse Gata4 AAV particle
    ORF Viral VectorvGMLPm004341mouse Gata4 Lentivirus particle


    Target information

    Target IDGM-T51817
    Target NameGATA4
    Gene ID2626,14463,54254,696775,486079,101086140,327716,100065126
    Gene Symbol and SynonymsASD2,Gata-4,GATA4,TACHD,TOF,VSD1
    Uniprot AccessionP43694,P46152,Q0Q0E4
    Uniprot Entry NameGATA4_HUMAN,GATA4_RAT,GATA4_CANLF
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseHead and Neck Cancer
    Gene EnsemblENSG00000136574
    Target ClassificationN/A

    The target: GATA4, gene name: GATA4, also named as ASD2, TACHD, TOF, VSD1. This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.