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Anti-GBRA1/ GABRA1/ ECA4 monoclonal antibody
Anti-GBRA1/ GABRA1/ ECA4 antibody for FACS & in-vivo assay
Go to GABRA1/GABRA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51487-Ab-1/ GM-Tg-hg-T51487-Ab-2 | Anti-Human GABRA1 monoclonal antibody | Human |
| GM-Tg-rg-T51487-Ab-1/ GM-Tg-rg-T51487-Ab-2 | Anti-Rat GABRA1 monoclonal antibody | Rat |
| GM-Tg-mg-T51487-Ab-1/ GM-Tg-mg-T51487-Ab-2 | Anti-Mouse GABRA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T51487-Ab-1/ GM-Tg-cynog-T51487-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GABRA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51487-Ab-1/ GM-Tg-felg-T51487-Ab-2 | Anti-Feline GABRA1 monoclonal antibody | Feline |
| GM-Tg-cang-T51487-Ab-1/ GM-Tg-cang-T51487-Ab-2 | Anti-Canine GABRA1 monoclonal antibody | Canine |
| GM-Tg-bovg-T51487-Ab-1/ GM-Tg-bovg-T51487-Ab-2 | Anti-Bovine GABRA1 monoclonal antibody | Bovine |
| GM-Tg-equg-T51487-Ab-1/ GM-Tg-equg-T51487-Ab-2 | Anti-Equine GABRA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51487-Ab-1/ GM-Tg-hg-T51487-Ab-2; GM-Tg-rg-T51487-Ab-1/ GM-Tg-rg-T51487-Ab-2; GM-Tg-mg-T51487-Ab-1/ GM-Tg-mg-T51487-Ab-2; GM-Tg-cynog-T51487-Ab-1/ GM-Tg-cynog-T51487-Ab-2; GM-Tg-felg-T51487-Ab-1/ GM-Tg-felg-T51487-Ab-2; GM-Tg-cang-T51487-Ab-1/ GM-Tg-cang-T51487-Ab-2; GM-Tg-bovg-T51487-Ab-1/ GM-Tg-bovg-T51487-Ab-2; GM-Tg-equg-T51487-Ab-1/ GM-Tg-equg-T51487-Ab-2 |
| Products Name | Anti-GABRA1 monoclonal antibody |
| Format | mab |
| Target Name | GABRA1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GABRA1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GBRA1/ GABRA1/ ECA4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001509 | human GABRA1 Lentivirus particle |
| ORF Viral Vector | pGMLP001509 | human GABRA1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002946 | mouse Gabra1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002946 | mouse Gabra1 Lentivirus particle |
Target information
| Target ID | GM-T51487 |
| Target Name | GABRA1 |
| Gene ID | 2554,14394,29705,574302,489143,100286792,780973,100070870 |
| Gene Symbol and Synonyms | DEE19,ECA4,EIEE19,EJM,EJM5,GABAA-alpha1,GABAAR-alpha1,Gabra-1,GABRA1 |
| Uniprot Accession | P14867,P62813,P08219 |
| Uniprot Entry Name | GBRA1_HUMAN,GBRA1_RAT,GBRA1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000022355 |
| Target Classification | Ion Channel |
The target: GABRA1, gene name: GABRA1, also named as ECA4, EIEE19, EJM, EJM5. This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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