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Anti-TNR16/ NGFR/ CD271 monoclonal antibody
Anti-TNR16/ NGFR/ CD271 antibody for FACS & in-vivo assay
Go to NGFR/NGFR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T50942-Ab-1/ GM-Tg-hg-T50942-Ab-2 | Anti-Human NGFR monoclonal antibody | Human |
| GM-Tg-rg-T50942-Ab-1/ GM-Tg-rg-T50942-Ab-2 | Anti-Rat NGFR monoclonal antibody | Rat |
| GM-Tg-mg-T50942-Ab-1/ GM-Tg-mg-T50942-Ab-2 | Anti-Mouse NGFR monoclonal antibody | Mouse |
| GM-Tg-cynog-T50942-Ab-1/ GM-Tg-cynog-T50942-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NGFR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T50942-Ab-1/ GM-Tg-felg-T50942-Ab-2 | Anti-Feline NGFR monoclonal antibody | Feline |
| GM-Tg-cang-T50942-Ab-1/ GM-Tg-cang-T50942-Ab-2 | Anti-Canine NGFR monoclonal antibody | Canine |
| GM-Tg-bovg-T50942-Ab-1/ GM-Tg-bovg-T50942-Ab-2 | Anti-Bovine NGFR monoclonal antibody | Bovine |
| GM-Tg-equg-T50942-Ab-1/ GM-Tg-equg-T50942-Ab-2 | Anti-Equine NGFR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T50942-Ab-1/ GM-Tg-hg-T50942-Ab-2; GM-Tg-rg-T50942-Ab-1/ GM-Tg-rg-T50942-Ab-2; GM-Tg-mg-T50942-Ab-1/ GM-Tg-mg-T50942-Ab-2; GM-Tg-cynog-T50942-Ab-1/ GM-Tg-cynog-T50942-Ab-2; GM-Tg-felg-T50942-Ab-1/ GM-Tg-felg-T50942-Ab-2; GM-Tg-cang-T50942-Ab-1/ GM-Tg-cang-T50942-Ab-2; GM-Tg-bovg-T50942-Ab-1/ GM-Tg-bovg-T50942-Ab-2; GM-Tg-equg-T50942-Ab-1/ GM-Tg-equg-T50942-Ab-2 |
| Products Name | Anti-NGFR monoclonal antibody |
| Format | mab |
| Target Name | NGFR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NGFR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TNR16/ NGFR/ CD271 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003686 | human NGFR Lentivirus plasmid |
| ORF Viral Vector | vGMLP003686 | human NGFR Lentivirus particle |
| ORF Viral Vector | pGMAAV000213 | house mouse Ngfr AAV plasmid |
| ORF Viral Vector | pGMLPm002516 | mouse Ngfr Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000213 | house mouse Ngfr AAV particle |
| ORF Viral Vector | vGMLPm002516 | mouse Ngfr Lentivirus particle |
Target information
| Target ID | GM-T50942 |
| Target Name | NGFR |
| Gene ID | 4804,18053,24596,574304,491071,101101519,353110,100069694 |
| Gene Symbol and Synonyms | CD271,Gp80-LNGFR,LNGFR,NGFR,p75,p75(NTR),p75NGFR,p75NTR,RNNGFRR,TNFRSF16 |
| Uniprot Accession | P08138,P07174 |
| Uniprot Entry Name | TNR16_HUMAN,TNR16_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000064300 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: NGFR, gene name: NGFR, also named as CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR. Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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