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Anti-CD86/ FUN1/ B7-2 monoclonal antibody
Anti-CD86/ FUN1/ B7-2 antibody for FACS & in-vivo assay
Go to FUN1/CD86 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T50912-Ab-1/ GM-Tg-hg-T50912-Ab-2 | Anti-Human FUN1/CD86 monoclonal antibody | Human |
| GM-Tg-rg-T50912-Ab-1/ GM-Tg-rg-T50912-Ab-2 | Anti-Rat FUN1/CD86 monoclonal antibody | Rat |
| GM-Tg-mg-T50912-Ab-1/ GM-Tg-mg-T50912-Ab-2 | Anti-Mouse FUN1/CD86 monoclonal antibody | Mouse |
| GM-Tg-cynog-T50912-Ab-1/ GM-Tg-cynog-T50912-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FUN1/CD86 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T50912-Ab-1/ GM-Tg-felg-T50912-Ab-2 | Anti-Feline FUN1/CD86 monoclonal antibody | Feline |
| GM-Tg-cang-T50912-Ab-1/ GM-Tg-cang-T50912-Ab-2 | Anti-Canine FUN1/CD86 monoclonal antibody | Canine |
| GM-Tg-bovg-T50912-Ab-1/ GM-Tg-bovg-T50912-Ab-2 | Anti-Bovine FUN1/CD86 monoclonal antibody | Bovine |
| GM-Tg-equg-T50912-Ab-1/ GM-Tg-equg-T50912-Ab-2 | Anti-Equine FUN1/CD86 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T50912-Ab-1/ GM-Tg-hg-T50912-Ab-2; GM-Tg-rg-T50912-Ab-1/ GM-Tg-rg-T50912-Ab-2; GM-Tg-mg-T50912-Ab-1/ GM-Tg-mg-T50912-Ab-2; GM-Tg-cynog-T50912-Ab-1/ GM-Tg-cynog-T50912-Ab-2; GM-Tg-felg-T50912-Ab-1/ GM-Tg-felg-T50912-Ab-2; GM-Tg-cang-T50912-Ab-1/ GM-Tg-cang-T50912-Ab-2; GM-Tg-bovg-T50912-Ab-1/ GM-Tg-bovg-T50912-Ab-2; GM-Tg-equg-T50912-Ab-1/ GM-Tg-equg-T50912-Ab-2 |
| Products Name | Anti-FUN1/CD86 monoclonal antibody |
| Format | mab |
| Target Name | FUN1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FUN1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CD86/ FUN1/ B7-2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004743 | human CD86 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004743 | human CD86 Lentivirus particle |
| ORF Viral Vector | pGMLPm001943 | mouse Cd86 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001943 | mouse Cd86 Lentivirus particle |
Target information
| Target ID | GM-T50912 |
| Target Name | FUN1 |
| Gene ID | 942,12524,56822,714390,403764,493704,414345,100060767 |
| Gene Symbol and Synonyms | B7,B7-2,B7.2,B70,Cd28l2,CD28LG2,CD86,CLS1,ETC-1,LAB72,Ly-58,Ly58,MB7,MB7-2,TS/A-2 |
| Uniprot Accession | P42081 |
| Uniprot Entry Name | CD86_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000114013 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FUN1, gene name: CD86, also named as B7-2, B7.2, B70, CD28LG2, LAB72. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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