Anti-PIM1 monoclonal antibody

Pre-made anti-PIM1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to PIM1/PIM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T50594-Ab-1/ GM-Tg-hg-T50594-Ab-2Anti-Human PIM1 monoclonal antibodyHuman
GM-Tg-rg-T50594-Ab-1/ GM-Tg-rg-T50594-Ab-2Anti-Rat PIM1 monoclonal antibodyRat
GM-Tg-mg-T50594-Ab-1/ GM-Tg-mg-T50594-Ab-2Anti-Mouse PIM1 monoclonal antibodyMouse
GM-Tg-cynog-T50594-Ab-1/ GM-Tg-cynog-T50594-Ab-2Anti-Cynomolgus/ Rhesus macaque PIM1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T50594-Ab-1/ GM-Tg-felg-T50594-Ab-2Anti-Feline PIM1 monoclonal antibodyFeline
GM-Tg-cang-T50594-Ab-1/ GM-Tg-cang-T50594-Ab-2Anti-Canine PIM1 monoclonal antibodyCanine
GM-Tg-bovg-T50594-Ab-1/ GM-Tg-bovg-T50594-Ab-2Anti-Bovine PIM1 monoclonal antibodyBovine
GM-Tg-equg-T50594-Ab-1/ GM-Tg-equg-T50594-Ab-2Anti-Equine PIM1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T50594-Ab-1/ GM-Tg-hg-T50594-Ab-2; GM-Tg-rg-T50594-Ab-1/ GM-Tg-rg-T50594-Ab-2;
GM-Tg-mg-T50594-Ab-1/ GM-Tg-mg-T50594-Ab-2; GM-Tg-cynog-T50594-Ab-1/ GM-Tg-cynog-T50594-Ab-2;
GM-Tg-felg-T50594-Ab-1/ GM-Tg-felg-T50594-Ab-2; GM-Tg-cang-T50594-Ab-1/ GM-Tg-cang-T50594-Ab-2;
GM-Tg-bovg-T50594-Ab-1/ GM-Tg-bovg-T50594-Ab-2; GM-Tg-equg-T50594-Ab-1/ GM-Tg-equg-T50594-Ab-2
Products NameAnti-PIM1 monoclonal antibody
Formatmab
Target NamePIM1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-PIM1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T50594-Ag-1Recombinant multi-species PIM1/ PIM protein
    ORF Viral VectorpGMAP000309Human PIM1 Adenovirus plasmid
    ORF Viral VectorvGMAP000309Human PIM1 Adenovirus particle
    ORF Viral VectorpGMLV000107rat Pim1 Lentivirus plasmid
    ORF Viral VectorpGMAAV000309house mouse Pim1 AAV plasmid
    ORF Viral VectorpGMLPm001265mouse Pim1 Lentivirus plasmid
    ORF Viral VectorvGMLV000107rat Pim1 Lentivirus particle
    ORF Viral VectorvGMAAV000309house mouse Pim1 AAV particle
    ORF Viral VectorvGMLPm001265mouse Pim1 Lentivirus particle


    Target information

    Target IDGM-T50594
    Target NamePIM1
    Gene ID5292,18712,24649,114677751,493888,281402,100053898
    Gene Symbol and SynonymsPIM,Pim-1,PIM1
    Uniprot AccessionP11309,P26794,Q95LJ0,Q9N0P9
    Uniprot Entry NamePIM1_HUMAN,PIM1_RAT,PIM1_FELCA,PIM1_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000137193
    Target ClassificationTumor-associated antigen (TAA)

    The target: PIM1, gene name: PIM1, also named as PIM. The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.