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Anti-TGFR2/ TGFBR2/ AAT3 monoclonal antibody
Anti-TGFR2/ TGFBR2/ AAT3 antibody for FACS & in-vivo assay
Go to TGFBR2/TGFBR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T49989-Ab-1/ GM-Tg-hg-T49989-Ab-2 | Anti-Human TGFBR2 monoclonal antibody | Human |
| GM-Tg-rg-T49989-Ab-1/ GM-Tg-rg-T49989-Ab-2 | Anti-Rat TGFBR2 monoclonal antibody | Rat |
| GM-Tg-mg-T49989-Ab-1/ GM-Tg-mg-T49989-Ab-2 | Anti-Mouse TGFBR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T49989-Ab-1/ GM-Tg-cynog-T49989-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TGFBR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T49989-Ab-1/ GM-Tg-felg-T49989-Ab-2 | Anti-Feline TGFBR2 monoclonal antibody | Feline |
| GM-Tg-cang-T49989-Ab-1/ GM-Tg-cang-T49989-Ab-2 | Anti-Canine TGFBR2 monoclonal antibody | Canine |
| GM-Tg-bovg-T49989-Ab-1/ GM-Tg-bovg-T49989-Ab-2 | Anti-Bovine TGFBR2 monoclonal antibody | Bovine |
| GM-Tg-equg-T49989-Ab-1/ GM-Tg-equg-T49989-Ab-2 | Anti-Equine TGFBR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T49989-Ab-1/ GM-Tg-hg-T49989-Ab-2; GM-Tg-rg-T49989-Ab-1/ GM-Tg-rg-T49989-Ab-2; GM-Tg-mg-T49989-Ab-1/ GM-Tg-mg-T49989-Ab-2; GM-Tg-cynog-T49989-Ab-1/ GM-Tg-cynog-T49989-Ab-2; GM-Tg-felg-T49989-Ab-1/ GM-Tg-felg-T49989-Ab-2; GM-Tg-cang-T49989-Ab-1/ GM-Tg-cang-T49989-Ab-2; GM-Tg-bovg-T49989-Ab-1/ GM-Tg-bovg-T49989-Ab-2; GM-Tg-equg-T49989-Ab-1/ GM-Tg-equg-T49989-Ab-2 |
| Products Name | Anti-TGFBR2 monoclonal antibody |
| Format | mab |
| Target Name | TGFBR2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TGFBR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-659 | Pre-Made Dalutrafusp biosimilar, Whole mAb, Anti-TGFBR2 Antibody: Anti-AAT3/FAA3/LDS1B/LDS2/LDS2B/MFS2/RIIC/TAAD2/TBR-ii/TBRII/TGFR-2-RII therapeutic antibody |
| Target Antigen | Products Developing | Multi-species TGFR2/ TGFBR2/ AAT3 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T49989-Ag-1 | transforming growth factor, beta receptor II (70/80kDa) (TGFBR2) protein |
| ORF Viral Vector | pGMLP001435 | human TGFBR2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001435 | human TGFBR2 Lentivirus particle |
| ORF Viral Vector | pGMLPm001726 | mouse Tgfbr2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001727 | mouse Tgfbr2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001726 | mouse Tgfbr2 Lentivirus particle |
| ORF Viral Vector | vGMLPm001727 | mouse Tgfbr2 Lentivirus particle |
Target information
| Target ID | GM-T49989 |
| Target Name | TGFBR2 |
| Gene ID | 7048,21813,81810,703088,477039,101091725,535376,100033860 |
| Gene Symbol and Synonyms | 1110020H15Rik,AAT3,DNIIR,FAA3,LDS1B,LDS2,LDS2B,MFS2,RIIC,RIIDN,TAAD2,TBETA-RII,tbetaR-II,TbetaRII,TBR-ii,TBRII,TGF-beta 2,TGFbeta-RII,TGFBR2,Tgfbr2T,TGFBRII,TGFR-2 |
| Uniprot Accession | P37173,P38438 |
| Uniprot Entry Name | TGFR2_HUMAN,TGFR2_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000163513 |
| Target Classification | Checkpoint-Immuno Oncology, Kinase, Tumor-associated antigen (TAA) |
The target: TGFBR2, gene name: TGFBR2, also named as AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TBR-ii, TBRII, TGFR-2, TGFbeta-RII. The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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