Human TGFBR2/AAT3/FAA3 ORF/cDNA clone-Lentivirus particle (NM_001024847)

Cat. No.: vGMLP001435

Pre-made Human TGFBR2/AAT3/FAA3 Lentiviral expression plasmid for TGFBR2 lentivirus packaging, TGFBR2 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLP001435 Human TGFBR2 Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLP001435
Gene Name TGFBR2
Accession Number NM_001024847
Gene ID 7048
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 1779 bp
Gene Alias AAT3,FAA3,LDS1B,LDS2,LDS2B,MFS2,RIIC,TAAD2,TGFbeta-RII,TGFR-2
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACCGCACGTTCAGAAGTCGGATGTGGAAATGGAGGCCCAGAAAGATGAAATCATCTGCCCCAGCTGTAATAGGACTGCCCATCCACTGAGACATATTAATAACGACATGATAGTCACTGACAACAACGGTGCAGTCAAGTTTCCACAACTGTGTAAATTTTGTGATGTGAGATTTTCCACCTGTGACAACCAGAAATCCTGCATGAGCAACTGCAGCATCACCTCCATCTGTGAGAAGCCACAGGAAGTCTGTGTGGCTGTATGGAGAAAGAATGACGAGAACATAACACTAGAGACAGTTTGCCATGACCCCAAGCTCCCCTACCATGACTTTATTCTGGAAGATGCTGCTTCTCCAAAGTGCATTATGAAGGAAAAAAAAAAGCCTGGTGAGACTTTCTTCATGTGTTCCTGTAGCTCTGATGAGTGCAATGACAACATCATCTTCTCAGAAGAATATAACACCAGCAATCCTGACTTGTTGCTAGTCATATTTCAAGTGACAGGCATCAGCCTCCTGCCACCACTGGGAGTTGCCATATCTGTCATCATCATCTTCTACTGCTACCGCGTTAACCGGCAGCAGAAGCTGAGTTCAACCTGGGAAACCGGCAAGACGCGGAAGCTCATGGAGTTCAGCGAGCACTGTGCCATCATCCTGGAAGATGACCGCTCTGACATCAGCTCCACGTGTGCCAACAACATCAACCACAACACAGAGCTGCTGCCCATTGAGCTGGACACCCTGGTGGGGAAAGGTCGCTTTGCTGAGGTCTATAAGGCCAAGCTGAAGCAGAACACTTCAGAGCAGTTTGAGACAGTGGCAGTCAAGATCTTTCCCTATGAGGAGTATGCCTCTTGGAAGACAGAGAAGGACATCTTCTCAGACATCAATCTGAAGCATGAGAACATACTCCAGTTCCTGACGGCTGAGGAGCGGAAGACGGAGTTGGGGAAACAATACTGGCTGATCACCGCCTTCCACGCCAAGGGCAACCTACAGGAGTACCTGACGCGGCATGTCATCAGCTGGGAGGACCTGCGCAAGCTGGGCAGCTCCCTCGCCCGGGGGATTGCTCACCTCCACAGTGATCACACTCCATGTGGGAGGCCCAAGATGCCCATCGTGCACAGGGACCTCAAGAGCTCCAATATCCTCGTGAAGAACGACCTAACCTGCTGCCTGTGTGACTTTGGGCTTTCCCTGCGTCTGGACCCTACTCTGTCTGTGGATGACCTGGCTAACAGTGGGCAGGTGGGAACTGCAAGATACATGGCTCCAGAAGTCCTAGAATCCAGGATGAATTTGGAGAATGTTGAGTCCTTCAAGCAGACCGATGTCTACTCCATGGCTCTGGTGCTCTGGGAAATGACATCTCGCTGTAATGCAGTGGGAGAAGTAAAAGATTATGAGCCTCCATTTGGTTCCAAGGTGCGGGAGCACCCCTGTGTCGAAAGCATGAAGGACAACGTGTTGAGAGATCGAGGGCGACCAGAAATTCCCAGCTTCTGGCTCAACCACCAGGGCATCCAGATGGTGTGTGAGACGTTGACTGAGTGCTGGGACCACGACCCAGAGGCCCGTCTCACAGCCCAGTGTGTGGCAGAACGCTTCAGTGAGCTGGAGCATCTGGACAGGCTCTCGGGGAGGAGCTGCTCGGAGGAGAAGATTCCTGAAGACGGCTCCCTAAACACTACCAAATAG
ORF Protein Sequence MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Biosimilar GMP-Bios-ab-659 Pre-Made Dalutrafusp biosimilar, Whole mAb, Anti-TGFBR2 Antibody: Anti-AAT3/FAA3/LDS1B/LDS2/LDS2B/MFS2/RIIC/TAAD2/TBR-ii/TBRII/TGFR-2-RII therapeutic antibody
    Target Antibody GM-Tg-g-T49989-Ab Anti-TGFR2/ TGFBR2/ AAT3 monoclonal antibody
    Target Antigen GM-Tg-g-T49989-Ag TGFBR2 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-T49989 transforming growth factor, beta receptor II (70/80kDa) (TGFBR2) protein & antibody
    ORF Viral Vector pGMLP001435 Human TGFBR2 Lentivirus plasmid
    ORF Viral Vector pGMLV002329 Human TGFBR2 Lentivirus plasmid
    ORF Viral Vector pGMLV002336 Human TGFBR2 Lentivirus plasmid
    ORF Viral Vector pGMLP-SPh-041 Human TGFBR2 Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-181 Human TGFBR2 Adenovirus plasmid
    ORF Viral Vector pGMPC000634 Human TGFBR2 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP001435 Human TGFBR2 Lentivirus particle
    ORF Viral Vector vGMLV002329 Human TGFBR2 Lentivirus particle
    ORF Viral Vector vGMLV002336 Human TGFBR2 Lentivirus particle
    ORF Viral Vector vGMLP-SPh-041 Human TGFBR2 Lentivirus particle
    ORF Viral Vector vGMAP-SPh-181 Human TGFBR2 Adenovirus particle


    Target information

    Target ID GM-T49989
    Target Name TGFBR2
    Gene ID 7048, 21813, 703088, 81810, 101091725, 477039, 535376, 100033860
    Gene Symbol and Synonyms 1110020H15Rik,AAT3,DNIIR,FAA3,LDS1B,LDS2,LDS2B,MFS2,RIIC,RIIDN,TAAD2,TBETA-RII,tbetaR-II,TbetaRII,TBR-ii,TBRII,TGF-beta 2,TGFbeta-RII,TGFBR2,Tgfbr2T,TGFBRII,TGFR-2
    Uniprot Accession P37173
    Uniprot Entry Name TGFR2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    Disease Cancer
    Gene Ensembl ENSG00000163513
    Target Classification Checkpoint-Immuno Oncology, Kinase, Tumor-associated antigen (TAA)

    The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]



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