Anti-OPRM/ MOP/ OPRM1 monoclonal antibody

Anti-OPRM/ MOP/ OPRM1 antibody for FACS & in-vivo assay

Target products collectionGo to MOP/OPRM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T47768-Ab-1/ GM-Tg-hg-T47768-Ab-2Anti-Human MOP/OPRM1 monoclonal antibodyHuman
GM-Tg-rg-T47768-Ab-1/ GM-Tg-rg-T47768-Ab-2Anti-Rat MOP/OPRM1 monoclonal antibodyRat
GM-Tg-mg-T47768-Ab-1/ GM-Tg-mg-T47768-Ab-2Anti-Mouse MOP/OPRM1 monoclonal antibodyMouse
GM-Tg-cynog-T47768-Ab-1/ GM-Tg-cynog-T47768-Ab-2Anti-Cynomolgus/ Rhesus macaque MOP/OPRM1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T47768-Ab-1/ GM-Tg-felg-T47768-Ab-2Anti-Feline MOP/OPRM1 monoclonal antibodyFeline
GM-Tg-cang-T47768-Ab-1/ GM-Tg-cang-T47768-Ab-2Anti-Canine MOP/OPRM1 monoclonal antibodyCanine
GM-Tg-bovg-T47768-Ab-1/ GM-Tg-bovg-T47768-Ab-2Anti-Bovine MOP/OPRM1 monoclonal antibodyBovine
GM-Tg-equg-T47768-Ab-1/ GM-Tg-equg-T47768-Ab-2Anti-Equine MOP/OPRM1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T47768-Ab-1/ GM-Tg-hg-T47768-Ab-2; GM-Tg-rg-T47768-Ab-1/ GM-Tg-rg-T47768-Ab-2;
GM-Tg-mg-T47768-Ab-1/ GM-Tg-mg-T47768-Ab-2; GM-Tg-cynog-T47768-Ab-1/ GM-Tg-cynog-T47768-Ab-2;
GM-Tg-felg-T47768-Ab-1/ GM-Tg-felg-T47768-Ab-2; GM-Tg-cang-T47768-Ab-1/ GM-Tg-cang-T47768-Ab-2;
GM-Tg-bovg-T47768-Ab-1/ GM-Tg-bovg-T47768-Ab-2; GM-Tg-equg-T47768-Ab-1/ GM-Tg-equg-T47768-Ab-2
Products NameAnti-MOP/OPRM1 monoclonal antibody
Formatmab
Target NameMOP
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MOP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species OPRM/ MOP/ OPRM1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP001411human OPRM1 Lentivirus plasmid
    ORF Viral VectorvGMLP001411human OPRM1 Lentivirus particle
    ORF Viral VectorpGMAAV000153rat Oprm1 AAV plasmid
    ORF Viral VectorpGMLPm004443mouse Oprm1 Lentivirus plasmid
    ORF Viral VectorvGMAAV000153rat Oprm1 AAV particle
    ORF Viral VectorvGMLPm004443mouse Oprm1 Lentivirus particle


    Target information

    Target IDGM-T47768
    Target NameMOP
    Gene ID4988,18390,25601,574141,484041,101084452,281958,100060029
    Gene Symbol and SynonymsLMOR,M-OR-1,MOP,MOP-R,MOR,MOR-1,MOR-1O,MOR1,MORA,muOR,OPRM,OPRM1,Oprrm1
    Uniprot AccessionP35372,P33535,Q9MYW9,P79350
    Uniprot Entry NameOPRM_HUMAN,OPRM_MACMU,OPRM_RAT,OPRM_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000112038
    Target ClassificationGPCR

    The target: MOP, gene name: OPRM1, also named as LMOR, M-OR-1, MOP, MOR, MOR1, OPRM. This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.