Anti-TNF10/ TNFSF10/ APO2L functional antibody

Anti-TNF10/ TNFSF10/ APO2L functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to TNFSF10/TNFSF10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T46084-Ab-1/ GM-Tg-hg-T46084-Ab-2Anti-Human TNFSF10 monoclonal antibodyHuman
GM-Tg-rg-T46084-Ab-1/ GM-Tg-rg-T46084-Ab-2Anti-Rat TNFSF10 monoclonal antibodyRat
GM-Tg-mg-T46084-Ab-1/ GM-Tg-mg-T46084-Ab-2Anti-Mouse TNFSF10 monoclonal antibodyMouse
GM-Tg-cynog-T46084-Ab-1/ GM-Tg-cynog-T46084-Ab-2Anti-Cynomolgus/ Rhesus macaque TNFSF10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T46084-Ab-1/ GM-Tg-felg-T46084-Ab-2Anti-Feline TNFSF10 monoclonal antibodyFeline
GM-Tg-cang-T46084-Ab-1/ GM-Tg-cang-T46084-Ab-2Anti-Canine TNFSF10 monoclonal antibodyCanine
GM-Tg-bovg-T46084-Ab-1/ GM-Tg-bovg-T46084-Ab-2Anti-Bovine TNFSF10 monoclonal antibodyBovine
GM-Tg-equg-T46084-Ab-1/ GM-Tg-equg-T46084-Ab-2Anti-Equine TNFSF10 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T46084-Ab-1/ GM-Tg-hg-T46084-Ab-2; GM-Tg-rg-T46084-Ab-1/ GM-Tg-rg-T46084-Ab-2;
GM-Tg-mg-T46084-Ab-1/ GM-Tg-mg-T46084-Ab-2; GM-Tg-cynog-T46084-Ab-1/ GM-Tg-cynog-T46084-Ab-2;
GM-Tg-felg-T46084-Ab-1/ GM-Tg-felg-T46084-Ab-2; GM-Tg-cang-T46084-Ab-1/ GM-Tg-cang-T46084-Ab-2;
GM-Tg-bovg-T46084-Ab-1/ GM-Tg-bovg-T46084-Ab-2; GM-Tg-equg-T46084-Ab-1/ GM-Tg-equg-T46084-Ab-2
Products NameAnti-TNFSF10 monoclonal antibody
Formatmab
Target NameTNFSF10
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFSF10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T46084-Ag-1Recombinant multi-species TNF10/ TNFSF10/ APO2L protein
    CytokineGM-Tg-g-T46084-Ag-1tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10) protein
    ORF Viral VectorpGMLPm001935mouse Tnfsf10 Lentivirus plasmid
    ORF Viral VectorvGMLPm001935mouse Tnfsf10 Lentivirus particle


    Target information

    Target IDGM-T46084
    Target NameTNFSF10
    Gene ID8743,22035,246775,694451,100174780,100174789,507215,100064377
    Gene Symbol and SynonymsA330042I21Rik,Apo-2L,APO2L,CD253,Ly81,TANCR,TL2,TNFSF10,TNLG6A,TRAIL
    Uniprot AccessionP50591
    Uniprot Entry NameTNF10_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseProstate Cancer
    Gene EnsemblENSG00000121858
    Target ClassificationCheckpoint-Immuno Oncology

    The target: TNFSF10, gene name: TNFSF10, also named as APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.