Anti-GRN/ PGRN/ CLN11 monoclonal antibody

Anti-GRN/ PGRN/ CLN11 antibody for FACS & in-vivo assay

Target products collectionGo to PGRN/GRN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T45182-Ab-1/ GM-Tg-hg-T45182-Ab-2Anti-Human PGRN/GRN monoclonal antibodyHuman
GM-Tg-rg-T45182-Ab-1/ GM-Tg-rg-T45182-Ab-2Anti-Rat PGRN/GRN monoclonal antibodyRat
GM-Tg-mg-T45182-Ab-1/ GM-Tg-mg-T45182-Ab-2Anti-Mouse PGRN/GRN monoclonal antibodyMouse
GM-Tg-cynog-T45182-Ab-1/ GM-Tg-cynog-T45182-Ab-2Anti-Cynomolgus/ Rhesus macaque PGRN/GRN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T45182-Ab-1/ GM-Tg-felg-T45182-Ab-2Anti-Feline PGRN/GRN monoclonal antibodyFeline
GM-Tg-cang-T45182-Ab-1/ GM-Tg-cang-T45182-Ab-2Anti-Canine PGRN/GRN monoclonal antibodyCanine
GM-Tg-bovg-T45182-Ab-1/ GM-Tg-bovg-T45182-Ab-2Anti-Bovine PGRN/GRN monoclonal antibodyBovine
GM-Tg-equg-T45182-Ab-1/ GM-Tg-equg-T45182-Ab-2Anti-Equine PGRN/GRN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T45182-Ab-1/ GM-Tg-hg-T45182-Ab-2; GM-Tg-rg-T45182-Ab-1/ GM-Tg-rg-T45182-Ab-2;
GM-Tg-mg-T45182-Ab-1/ GM-Tg-mg-T45182-Ab-2; GM-Tg-cynog-T45182-Ab-1/ GM-Tg-cynog-T45182-Ab-2;
GM-Tg-felg-T45182-Ab-1/ GM-Tg-felg-T45182-Ab-2; GM-Tg-cang-T45182-Ab-1/ GM-Tg-cang-T45182-Ab-2;
GM-Tg-bovg-T45182-Ab-1/ GM-Tg-bovg-T45182-Ab-2; GM-Tg-equg-T45182-Ab-1/ GM-Tg-equg-T45182-Ab-2
Products NameAnti-PGRN/GRN monoclonal antibody
Formatmab
Target NamePGRN
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PGRN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GRN/ PGRN/ CLN11 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMAP000509Human GRN Adenovirus particle
    ORF Viral VectorpGMAP000509Human GRN Adenovirus plasmid
    ORF Viral VectorvGMLP003819human GRN Lentivirus particle
    ORF Viral VectorpGMLP003819human GRN Lentivirus plasmid
    ORF Viral VectorpGMLPm004393mouse Grn Lentivirus plasmid
    ORF Viral VectorvGMLPm004393mouse Grn Lentivirus particle


    Target information

    Target IDGM-T45182
    Target NamePGRN
    Gene ID2896,14824,29143,714851,480501,101100680,767942,100051035
    Gene Symbol and SynonymsCLN11,epithelin,GEP,GP88,GRN,PCDGF,PEPI,PGRN
    Uniprot AccessionP28799,P23785
    Uniprot Entry NameGRN_HUMAN,GRN_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseOvary Cancer, Type 1 diabetes mellitus
    Gene EnsemblENSG00000030582
    Target ClassificationN/A

    The target: PGRN, gene name: GRN, also named as CLN11, GEP, GP88, PCDGF, PEPI, PGRN. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.