Anti-CEAM6/ CD66c/ CEACAM6 monoclonal antibody

Anti-CEAM6/ CD66c/ CEACAM6 antibody for FACS & in-vivo assay

Target products collectionGo to CD66c/CEACAM6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T44513-Ab-1/ GM-Tg-hg-T44513-Ab-2Anti-Human CD66c/CEACAM6 monoclonal antibodyHuman
GM-Tg-rg-T44513-Ab-1/ GM-Tg-rg-T44513-Ab-2Anti-Rat CD66c/CEACAM6 monoclonal antibodyRat
GM-Tg-mg-T44513-Ab-1/ GM-Tg-mg-T44513-Ab-2Anti-Mouse CD66c/CEACAM6 monoclonal antibodyMouse
GM-Tg-cynog-T44513-Ab-1/ GM-Tg-cynog-T44513-Ab-2Anti-Cynomolgus/ Rhesus macaque CD66c/CEACAM6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T44513-Ab-1/ GM-Tg-felg-T44513-Ab-2Anti-Feline CD66c/CEACAM6 monoclonal antibodyFeline
GM-Tg-cang-T44513-Ab-1/ GM-Tg-cang-T44513-Ab-2Anti-Canine CD66c/CEACAM6 monoclonal antibodyCanine
GM-Tg-bovg-T44513-Ab-1/ GM-Tg-bovg-T44513-Ab-2Anti-Bovine CD66c/CEACAM6 monoclonal antibodyBovine
GM-Tg-equg-T44513-Ab-1/ GM-Tg-equg-T44513-Ab-2Anti-Equine CD66c/CEACAM6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T44513-Ab-1/ GM-Tg-hg-T44513-Ab-2; GM-Tg-rg-T44513-Ab-1/ GM-Tg-rg-T44513-Ab-2;
GM-Tg-mg-T44513-Ab-1/ GM-Tg-mg-T44513-Ab-2; GM-Tg-cynog-T44513-Ab-1/ GM-Tg-cynog-T44513-Ab-2;
GM-Tg-felg-T44513-Ab-1/ GM-Tg-felg-T44513-Ab-2; GM-Tg-cang-T44513-Ab-1/ GM-Tg-cang-T44513-Ab-2;
GM-Tg-bovg-T44513-Ab-1/ GM-Tg-bovg-T44513-Ab-2; GM-Tg-equg-T44513-Ab-1/ GM-Tg-equg-T44513-Ab-2
Products NameAnti-CD66c/CEACAM6 monoclonal antibody
Formatmab
Target NameCD66c
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD66c benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-578Pre-Made Tinurilimab biosimilar, Whole mAb, Anti-CEACAM6/CD66c Antibody: Anti-CEAL/NCA therapeutic antibody
    BiosimilarGMP-Bios-INN-886Pre-Made Lemalesomab Biosimilar, Whole Mab: Anti-Nca-90 (Nonspecific Cross- Reacting Antigens 90Kda Glycoproteins, Granulocyte Cell Antigen) [human] therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CEAM6/ CD66c/ CEACAM6 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001615human CEACAM6 Lentivirus particle
    ORF Viral VectorpGMLP001615human CEACAM6 Lentivirus plasmid


    Target information

    Target IDGM-T44513
    Target NameCD66c
    Gene ID4680,106994775
    Gene Symbol and SynonymsCD66c,CEACAM6,CEAL,NCA
    Uniprot AccessionP40199
    Uniprot Entry NameCEAM6_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000086548
    Target ClassificationTumor-associated antigen (TAA)

    The target: CD66c, gene name: CEACAM6, also named as CD66c, CEAL, NCA. This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.