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Anti-I12R2/ IL12RB2 monoclonal antibody
Anti-I12R2/ IL12RB2 antibody for FACS & in-vivo assay
Go to IL12RB2/IL12RB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T43524-Ab-1/ GM-Tg-hg-T43524-Ab-2 | Anti-Human IL12RB2 monoclonal antibody | Human |
| GM-Tg-rg-T43524-Ab-1/ GM-Tg-rg-T43524-Ab-2 | Anti-Rat IL12RB2 monoclonal antibody | Rat |
| GM-Tg-mg-T43524-Ab-1/ GM-Tg-mg-T43524-Ab-2 | Anti-Mouse IL12RB2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T43524-Ab-1/ GM-Tg-cynog-T43524-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL12RB2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T43524-Ab-1/ GM-Tg-felg-T43524-Ab-2 | Anti-Feline IL12RB2 monoclonal antibody | Feline |
| GM-Tg-cang-T43524-Ab-1/ GM-Tg-cang-T43524-Ab-2 | Anti-Canine IL12RB2 monoclonal antibody | Canine |
| GM-Tg-bovg-T43524-Ab-1/ GM-Tg-bovg-T43524-Ab-2 | Anti-Bovine IL12RB2 monoclonal antibody | Bovine |
| GM-Tg-equg-T43524-Ab-1/ GM-Tg-equg-T43524-Ab-2 | Anti-Equine IL12RB2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T43524-Ab-1/ GM-Tg-hg-T43524-Ab-2; GM-Tg-rg-T43524-Ab-1/ GM-Tg-rg-T43524-Ab-2; GM-Tg-mg-T43524-Ab-1/ GM-Tg-mg-T43524-Ab-2; GM-Tg-cynog-T43524-Ab-1/ GM-Tg-cynog-T43524-Ab-2; GM-Tg-felg-T43524-Ab-1/ GM-Tg-felg-T43524-Ab-2; GM-Tg-cang-T43524-Ab-1/ GM-Tg-cang-T43524-Ab-2; GM-Tg-bovg-T43524-Ab-1/ GM-Tg-bovg-T43524-Ab-2; GM-Tg-equg-T43524-Ab-1/ GM-Tg-equg-T43524-Ab-2 |
| Products Name | Anti-IL12RB2 monoclonal antibody |
| Format | mab |
| Target Name | IL12RB2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL12RB2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species I12R2/ IL12RB2 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T43524-Ag-1 | interleukin 12 receptor, beta 2 (IL12RB2) protein |
Target information
| Target ID | GM-T43524 |
| Target Name | IL12RB2 |
| Gene ID | 3595,16162,171334,700677,489550,101088012,282452,100053757 |
| Gene Symbol and Synonyms | A930027I18Rik,Ifnm,IL-12RB2,IL12RB2 |
| Uniprot Accession | Q99665,Q9BEG2 |
| Uniprot Entry Name | I12R2_HUMAN,I12R2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000081985 |
| Target Classification | N/A |
The target: IL12RB2, gene name: IL12RB2, also named as . The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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