Anti-KCNN4/ DHS2/ IK monoclonal antibody
Anti-KCNN4/ DHS2/ IK antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T42724-Ab-1/ GM-Tg-hg-T42724-Ab-2 | Anti-Human KCNN4 monoclonal antibody | Human |
GM-Tg-rg-T42724-Ab-1/ GM-Tg-rg-T42724-Ab-2 | Anti-Rat KCNN4 monoclonal antibody | Rat |
GM-Tg-mg-T42724-Ab-1/ GM-Tg-mg-T42724-Ab-2 | Anti-Mouse KCNN4 monoclonal antibody | Mouse |
GM-Tg-cynog-T42724-Ab-1/ GM-Tg-cynog-T42724-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNN4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T42724-Ab-1/ GM-Tg-felg-T42724-Ab-2 | Anti-Feline KCNN4 monoclonal antibody | Feline |
GM-Tg-cang-T42724-Ab-1/ GM-Tg-cang-T42724-Ab-2 | Anti-Canine KCNN4 monoclonal antibody | Canine |
GM-Tg-bovg-T42724-Ab-1/ GM-Tg-bovg-T42724-Ab-2 | Anti-Bovine KCNN4 monoclonal antibody | Bovine |
GM-Tg-equg-T42724-Ab-1/ GM-Tg-equg-T42724-Ab-2 | Anti-Equine KCNN4 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T42724-Ab-1/ GM-Tg-hg-T42724-Ab-2; GM-Tg-rg-T42724-Ab-1/ GM-Tg-rg-T42724-Ab-2; GM-Tg-mg-T42724-Ab-1/ GM-Tg-mg-T42724-Ab-2; GM-Tg-cynog-T42724-Ab-1/ GM-Tg-cynog-T42724-Ab-2; GM-Tg-felg-T42724-Ab-1/ GM-Tg-felg-T42724-Ab-2; GM-Tg-cang-T42724-Ab-1/ GM-Tg-cang-T42724-Ab-2; GM-Tg-bovg-T42724-Ab-1/ GM-Tg-bovg-T42724-Ab-2; GM-Tg-equg-T42724-Ab-1/ GM-Tg-equg-T42724-Ab-2 |
Products Name | Anti-KCNN4 monoclonal antibody |
Format | mab |
Target Name | KCNN4 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-KCNN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species KCNN4/ DHS2/ IK VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLV000294 | human KCNN4 Lentivirus particle |
ORF Viral Vector | pGMLV000294 | human KCNN4 Lentivirus plasmid |
ORF Viral Vector | vGMLV000498 | human KCNN4 Lentivirus particle |
ORF Viral Vector | pGMLV000498 | human KCNN4 Lentivirus plasmid |
ORF Viral Vector | pGMAD000078 | mouse Kcnn4 Adenovirus plasmid |
ORF Viral Vector | vGMAD000078 | mouse Kcnn4 Adenovirus particle |
Target information
Target ID | GM-T42724 |
Target Name | KCNN4 |
Gene ID | 3783,16534,65206,712383,484464,101090475,534591,100147493 |
Gene Symbol and Synonyms | DHS2,hIKCa1,hKCa4,hSK4,IK,IK1,IKCA1,KCa3.1,KCA4,KCNN4,mIKCa1,rKCNN4c,rSK4,SK4,SKCas |
Uniprot Accession | O15554,Q9QYW1 |
Uniprot Entry Name | KCNN4_HUMAN,KCNN4_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000104783 |
Target Classification | N/A |
The target: KCNN4, gene name: KCNN4, also named as DHS2, IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4. The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.