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Anti-LPAR2/ EDG-4/ EDG4 monoclonal antibody
Anti-LPAR2/ EDG-4/ EDG4 antibody for FACS & in-vivo assay
Go to LPAR2/LPAR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T39380-Ab-1/ GM-Tg-hg-T39380-Ab-2 | Anti-Human LPAR2 monoclonal antibody | Human |
| GM-Tg-rg-T39380-Ab-1/ GM-Tg-rg-T39380-Ab-2 | Anti-Rat LPAR2 monoclonal antibody | Rat |
| GM-Tg-mg-T39380-Ab-1/ GM-Tg-mg-T39380-Ab-2 | Anti-Mouse LPAR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T39380-Ab-1/ GM-Tg-cynog-T39380-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LPAR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T39380-Ab-1/ GM-Tg-felg-T39380-Ab-2 | Anti-Feline LPAR2 monoclonal antibody | Feline |
| GM-Tg-cang-T39380-Ab-1/ GM-Tg-cang-T39380-Ab-2 | Anti-Canine LPAR2 monoclonal antibody | Canine |
| GM-Tg-bovg-T39380-Ab-1/ GM-Tg-bovg-T39380-Ab-2 | Anti-Bovine LPAR2 monoclonal antibody | Bovine |
| GM-Tg-equg-T39380-Ab-1/ GM-Tg-equg-T39380-Ab-2 | Anti-Equine LPAR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T39380-Ab-1/ GM-Tg-hg-T39380-Ab-2; GM-Tg-rg-T39380-Ab-1/ GM-Tg-rg-T39380-Ab-2; GM-Tg-mg-T39380-Ab-1/ GM-Tg-mg-T39380-Ab-2; GM-Tg-cynog-T39380-Ab-1/ GM-Tg-cynog-T39380-Ab-2; GM-Tg-felg-T39380-Ab-1/ GM-Tg-felg-T39380-Ab-2; GM-Tg-cang-T39380-Ab-1/ GM-Tg-cang-T39380-Ab-2; GM-Tg-bovg-T39380-Ab-1/ GM-Tg-bovg-T39380-Ab-2; GM-Tg-equg-T39380-Ab-1/ GM-Tg-equg-T39380-Ab-2 |
| Products Name | Anti-LPAR2 monoclonal antibody |
| Format | mab |
| Target Name | LPAR2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LPAR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LPAR2/ EDG-4/ EDG4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003145 | human LPAR2 Lentivirus particle |
| ORF Viral Vector | pGMLP003145 | human LPAR2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000233 | human LPAR2 Lentivirus particle |
| ORF Viral Vector | pGMLV000233 | human LPAR2 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000569 | house mouse Lpar2 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm001715 | mouse Lpar2 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000569 | house mouse Lpar2 Adenovirus particle |
| ORF Viral Vector | vGMLPm001715 | mouse Lpar2 Lentivirus particle |
Target information
| Target ID | GM-T39380 |
| Target Name | LPAR2 |
| Gene ID | 9170,53978,498609,719844,484802,101100950,509748,102147510 |
| Gene Symbol and Synonyms | EDG-4,EDG4,IPA2,LPA-2,LPA2,LPAR2,PBX4,RGD1561336 |
| Uniprot Accession | Q9HBW0 |
| Uniprot Entry Name | LPAR2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000064547 |
| Target Classification | GPCR |
The target: LPAR2, gene name: LPAR2, also named as EDG-4, EDG4, LPA-2, LPA2. This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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