Anti-TNF15/ TNFSF15/ TL1 monoclonal antibody

Anti-TNF15/ TNFSF15/ TL1 antibody for FACS & in-vivo assay

Target products collectionGo to TNFSF15/TNFSF15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T35212-Ab-1/ GM-Tg-hg-T35212-Ab-2Anti-Human TNFSF15 monoclonal antibodyHuman
GM-Tg-rg-T35212-Ab-1/ GM-Tg-rg-T35212-Ab-2Anti-Rat TNFSF15 monoclonal antibodyRat
GM-Tg-mg-T35212-Ab-1/ GM-Tg-mg-T35212-Ab-2Anti-Mouse TNFSF15 monoclonal antibodyMouse
GM-Tg-cynog-T35212-Ab-1/ GM-Tg-cynog-T35212-Ab-2Anti-Cynomolgus/ Rhesus macaque TNFSF15 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T35212-Ab-1/ GM-Tg-felg-T35212-Ab-2Anti-Feline TNFSF15 monoclonal antibodyFeline
GM-Tg-cang-T35212-Ab-1/ GM-Tg-cang-T35212-Ab-2Anti-Canine TNFSF15 monoclonal antibodyCanine
GM-Tg-bovg-T35212-Ab-1/ GM-Tg-bovg-T35212-Ab-2Anti-Bovine TNFSF15 monoclonal antibodyBovine
GM-Tg-equg-T35212-Ab-1/ GM-Tg-equg-T35212-Ab-2Anti-Equine TNFSF15 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T35212-Ab-1/ GM-Tg-hg-T35212-Ab-2; GM-Tg-rg-T35212-Ab-1/ GM-Tg-rg-T35212-Ab-2;
GM-Tg-mg-T35212-Ab-1/ GM-Tg-mg-T35212-Ab-2; GM-Tg-cynog-T35212-Ab-1/ GM-Tg-cynog-T35212-Ab-2;
GM-Tg-felg-T35212-Ab-1/ GM-Tg-felg-T35212-Ab-2; GM-Tg-cang-T35212-Ab-1/ GM-Tg-cang-T35212-Ab-2;
GM-Tg-bovg-T35212-Ab-1/ GM-Tg-bovg-T35212-Ab-2; GM-Tg-equg-T35212-Ab-1/ GM-Tg-equg-T35212-Ab-2
Products NameAnti-TNFSF15 monoclonal antibody
Formatmab
Target NameTNFSF15
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFSF15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TNF15/ TNFSF15/ TL1 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T35212-Ag-1Tumor necrosis factor superfamily member 15 (TNFSF15) protein
    ORF Viral VectorpGMLP004530human TNFSF15 Lentivirus plasmid
    ORF Viral VectorvGMLP004530human TNFSF15 Lentivirus particle
    ORF Viral VectorpGMAAV000281human TNFSF15 AAV plasmid
    ORF Viral VectorvGMAAV000281human TNFSF15 AAV particle
    ORF Viral VectorpGMLPm000509mouse Tnfsf15 Lentivirus plasmid
    ORF Viral VectorvGMLPm000509mouse Tnfsf15 Lentivirus particle


    Target information

    Target IDGM-T35212
    Target NameTNFSF15
    Gene ID9966,326623,252878,703189,481688,101099505,514239,100049906
    Gene Symbol and SynonymsTL1,TL1A,TNFSF15,TNLG1B,VEGI,VEGI192A
    Uniprot AccessionO95150,Q8K3Y7
    Uniprot Entry NameTNF15_HUMAN,TNF15_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000181634
    Target ClassificationN/A

    The target: TNFSF15, gene name: TNFSF15, also named as TL1, TL1A, TNLG1B, VEGI, VEGI192A. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.