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Anti-X3CL1/ CX3CL1/ ABCD-3 monoclonal antibody
Anti-X3CL1/ CX3CL1/ ABCD-3 antibody for FACS & in-vivo assay
Go to CX3CL1/CX3CL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T34405-Ab-1/ GM-Tg-hg-T34405-Ab-2 | Anti-Human CX3CL1 monoclonal antibody | Human |
| GM-Tg-rg-T34405-Ab-1/ GM-Tg-rg-T34405-Ab-2 | Anti-Rat CX3CL1 monoclonal antibody | Rat |
| GM-Tg-mg-T34405-Ab-1/ GM-Tg-mg-T34405-Ab-2 | Anti-Mouse CX3CL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T34405-Ab-1/ GM-Tg-cynog-T34405-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CX3CL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T34405-Ab-1/ GM-Tg-felg-T34405-Ab-2 | Anti-Feline CX3CL1 monoclonal antibody | Feline |
| GM-Tg-cang-T34405-Ab-1/ GM-Tg-cang-T34405-Ab-2 | Anti-Canine CX3CL1 monoclonal antibody | Canine |
| GM-Tg-bovg-T34405-Ab-1/ GM-Tg-bovg-T34405-Ab-2 | Anti-Bovine CX3CL1 monoclonal antibody | Bovine |
| GM-Tg-equg-T34405-Ab-1/ GM-Tg-equg-T34405-Ab-2 | Anti-Equine CX3CL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T34405-Ab-1/ GM-Tg-hg-T34405-Ab-2; GM-Tg-rg-T34405-Ab-1/ GM-Tg-rg-T34405-Ab-2; GM-Tg-mg-T34405-Ab-1/ GM-Tg-mg-T34405-Ab-2; GM-Tg-cynog-T34405-Ab-1/ GM-Tg-cynog-T34405-Ab-2; GM-Tg-felg-T34405-Ab-1/ GM-Tg-felg-T34405-Ab-2; GM-Tg-cang-T34405-Ab-1/ GM-Tg-cang-T34405-Ab-2; GM-Tg-bovg-T34405-Ab-1/ GM-Tg-bovg-T34405-Ab-2; GM-Tg-equg-T34405-Ab-1/ GM-Tg-equg-T34405-Ab-2 |
| Products Name | Anti-CX3CL1 monoclonal antibody |
| Format | mab |
| Target Name | CX3CL1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CX3CL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-461 | Pre-Made Quetmolimab biosimilar, Whole mAb, Anti-CX3CL1 Antibody: Anti-ABCD-3/C3Xkine/CXC3/CXC3C/NTN/NTT/SCYD1/fractalkine/neurotactin therapeutic antibody |
| Target Antigen | Products Developing | Multi-species X3CL1/ CX3CL1/ ABCD-3 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T34405-Ag-1 | chemokine (C-X3-C motif) ligand 1 (CX3CL1) protein |
| ORF Viral Vector | vGMLV000860 | human CX3CL1 Lentivirus particle |
| ORF Viral Vector | vGMLP001884 | human CX3CL1 Lentivirus particle |
| ORF Viral Vector | pGMLP001884 | human CX3CL1 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000860 | human CX3CL1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002323 | mouse Cx3cl1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002323 | mouse Cx3cl1 Lentivirus particle |
Target information
| Target ID | GM-T34405 |
| Target Name | CX3CL1 |
| Gene ID | 6376,20312,89808,574225,487265,101084670,517354,102150350 |
| Gene Symbol and Synonyms | ABCD-3,C3Xkine,CX3C,CX3CL1,CXC3,CXC3C,D8Bwg0439e,FK,fractalkine,neurotactin,NTN,NTT,SCYD1 |
| Uniprot Accession | P78423,O55145 |
| Uniprot Entry Name | X3CL1_HUMAN,X3CL1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000006210 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: CX3CL1, gene name: CX3CL1, also named as ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin. This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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