Anti-VDR monoclonal antibody

Pre-made anti-VDR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to VDR/VDR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T34234-Ab-1/ GM-Tg-hg-T34234-Ab-2Anti-Human VDR monoclonal antibodyHuman
GM-Tg-rg-T34234-Ab-1/ GM-Tg-rg-T34234-Ab-2Anti-Rat VDR monoclonal antibodyRat
GM-Tg-mg-T34234-Ab-1/ GM-Tg-mg-T34234-Ab-2Anti-Mouse VDR monoclonal antibodyMouse
GM-Tg-cynog-T34234-Ab-1/ GM-Tg-cynog-T34234-Ab-2Anti-Cynomolgus/ Rhesus macaque VDR monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T34234-Ab-1/ GM-Tg-felg-T34234-Ab-2Anti-Feline VDR monoclonal antibodyFeline
GM-Tg-cang-T34234-Ab-1/ GM-Tg-cang-T34234-Ab-2Anti-Canine VDR monoclonal antibodyCanine
GM-Tg-bovg-T34234-Ab-1/ GM-Tg-bovg-T34234-Ab-2Anti-Bovine VDR monoclonal antibodyBovine
GM-Tg-equg-T34234-Ab-1/ GM-Tg-equg-T34234-Ab-2Anti-Equine VDR monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T34234-Ab-1/ GM-Tg-hg-T34234-Ab-2; GM-Tg-rg-T34234-Ab-1/ GM-Tg-rg-T34234-Ab-2;
GM-Tg-mg-T34234-Ab-1/ GM-Tg-mg-T34234-Ab-2; GM-Tg-cynog-T34234-Ab-1/ GM-Tg-cynog-T34234-Ab-2;
GM-Tg-felg-T34234-Ab-1/ GM-Tg-felg-T34234-Ab-2; GM-Tg-cang-T34234-Ab-1/ GM-Tg-cang-T34234-Ab-2;
GM-Tg-bovg-T34234-Ab-1/ GM-Tg-bovg-T34234-Ab-2; GM-Tg-equg-T34234-Ab-1/ GM-Tg-equg-T34234-Ab-2
Products NameAnti-VDR monoclonal antibody
Formatmab
Target NameVDR
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-VDR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T34234-Ag-1Recombinant multi-species VDR/ NR1I1/ PPP1R163 protein
    ORF Viral VectorvGMAP000353Human VDR Adenovirus particle
    ORF Viral VectorpGMLV000428human VDR Lentivirus plasmid
    ORF Viral VectorpGMAP000353Human VDR Adenovirus plasmid
    ORF Viral VectorvGMLV000428human VDR Lentivirus particle
    ORF Viral VectorpGMAD000223mouse Vdr Adenovirus plasmid
    ORF Viral VectorpGMLPm001255mouse Vdr Lentivirus plasmid
    ORF Viral VectorvGMAD000223mouse Vdr Adenovirus particle
    ORF Viral VectorvGMLPm001255mouse Vdr Lentivirus particle


    Target information

    Target IDGM-T34234
    Target NameVDR
    Gene ID7421,22337,24873,706964,486588,100316614,533656,100034072
    Gene Symbol and SynonymsNR1I1,PPP1R163,VDR
    Uniprot AccessionP11473,P13053,Q28037
    Uniprot Entry NameVDR_HUMAN,VDR_RAT,VDR_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000111424
    Target ClassificationN/A

    The target: VDR, gene name: VDR, also named as NR1I1, PPP1R163. This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.