- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-CALRL/ CGRPR/ CALCRL monoclonal antibody
Anti-CALRL/ CGRPR/ CALCRL antibody for FACS & in-vivo assay
Go to CGRPR/CALCRL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T32262-Ab-1/ GM-Tg-hg-T32262-Ab-2 | Anti-Human CGRPR/CALCRL monoclonal antibody | Human |
| GM-Tg-rg-T32262-Ab-1/ GM-Tg-rg-T32262-Ab-2 | Anti-Rat CGRPR/CALCRL monoclonal antibody | Rat |
| GM-Tg-mg-T32262-Ab-1/ GM-Tg-mg-T32262-Ab-2 | Anti-Mouse CGRPR/CALCRL monoclonal antibody | Mouse |
| GM-Tg-cynog-T32262-Ab-1/ GM-Tg-cynog-T32262-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CGRPR/CALCRL monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T32262-Ab-1/ GM-Tg-felg-T32262-Ab-2 | Anti-Feline CGRPR/CALCRL monoclonal antibody | Feline |
| GM-Tg-cang-T32262-Ab-1/ GM-Tg-cang-T32262-Ab-2 | Anti-Canine CGRPR/CALCRL monoclonal antibody | Canine |
| GM-Tg-bovg-T32262-Ab-1/ GM-Tg-bovg-T32262-Ab-2 | Anti-Bovine CGRPR/CALCRL monoclonal antibody | Bovine |
| GM-Tg-equg-T32262-Ab-1/ GM-Tg-equg-T32262-Ab-2 | Anti-Equine CGRPR/CALCRL monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T32262-Ab-1/ GM-Tg-hg-T32262-Ab-2; GM-Tg-rg-T32262-Ab-1/ GM-Tg-rg-T32262-Ab-2; GM-Tg-mg-T32262-Ab-1/ GM-Tg-mg-T32262-Ab-2; GM-Tg-cynog-T32262-Ab-1/ GM-Tg-cynog-T32262-Ab-2; GM-Tg-felg-T32262-Ab-1/ GM-Tg-felg-T32262-Ab-2; GM-Tg-cang-T32262-Ab-1/ GM-Tg-cang-T32262-Ab-2; GM-Tg-bovg-T32262-Ab-1/ GM-Tg-bovg-T32262-Ab-2; GM-Tg-equg-T32262-Ab-1/ GM-Tg-equg-T32262-Ab-2 |
| Products Name | Anti-CGRPR/CALCRL monoclonal antibody |
| Format | mab |
| Target Name | CGRPR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CGRPR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-193 | Pre-Made Erenumab biosimilar, Whole mAb, Anti-CALCRL/CGRPR Antibody: Anti-CRLR/LMPHM8 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species CALRL/ CGRPR/ CALCRL VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003725 | human CALCRL Lentivirus particle |
| ORF Viral Vector | pGMLP003725 | human CALCRL Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002810 | mouse Calcrl Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002810 | mouse Calcrl Lentivirus particle |
Target information
| Target ID | GM-T32262 |
| Target Name | CGRPR |
| Gene ID | 10203,54598,25029,708187,488438,101086333,527140,100054281 |
| Gene Symbol and Synonyms | CALCRL,CGRPR,CLR,CRLR,LMPHM8,RATCRLR,RNCLR |
| Uniprot Accession | Q16602,Q63118,A6QP74 |
| Uniprot Entry Name | CALRL_HUMAN,CALRL_RAT,CALRL_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000064989 |
| Target Classification | N/A |
The target: CGRPR, gene name: CALCRL, also named as CGRPR, CRLR. Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
