Anti-DPP4/ DPP-4/ ADABP monoclonal antibody

Anti-DPP4/ DPP-4/ ADABP antibody for FACS & in-vivo assay

Target products collectionGo to DPP-4/DPP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T31391-Ab-1/ GM-Tg-hg-T31391-Ab-2Anti-Human DPP-4/DPP4 monoclonal antibodyHuman
GM-Tg-rg-T31391-Ab-1/ GM-Tg-rg-T31391-Ab-2Anti-Rat DPP-4/DPP4 monoclonal antibodyRat
GM-Tg-mg-T31391-Ab-1/ GM-Tg-mg-T31391-Ab-2Anti-Mouse DPP-4/DPP4 monoclonal antibodyMouse
GM-Tg-cynog-T31391-Ab-1/ GM-Tg-cynog-T31391-Ab-2Anti-Cynomolgus/ Rhesus macaque DPP-4/DPP4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T31391-Ab-1/ GM-Tg-felg-T31391-Ab-2Anti-Feline DPP-4/DPP4 monoclonal antibodyFeline
GM-Tg-cang-T31391-Ab-1/ GM-Tg-cang-T31391-Ab-2Anti-Canine DPP-4/DPP4 monoclonal antibodyCanine
GM-Tg-bovg-T31391-Ab-1/ GM-Tg-bovg-T31391-Ab-2Anti-Bovine DPP-4/DPP4 monoclonal antibodyBovine
GM-Tg-equg-T31391-Ab-1/ GM-Tg-equg-T31391-Ab-2Anti-Equine DPP-4/DPP4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T31391-Ab-1/ GM-Tg-hg-T31391-Ab-2; GM-Tg-rg-T31391-Ab-1/ GM-Tg-rg-T31391-Ab-2;
GM-Tg-mg-T31391-Ab-1/ GM-Tg-mg-T31391-Ab-2; GM-Tg-cynog-T31391-Ab-1/ GM-Tg-cynog-T31391-Ab-2;
GM-Tg-felg-T31391-Ab-1/ GM-Tg-felg-T31391-Ab-2; GM-Tg-cang-T31391-Ab-1/ GM-Tg-cang-T31391-Ab-2;
GM-Tg-bovg-T31391-Ab-1/ GM-Tg-bovg-T31391-Ab-2; GM-Tg-equg-T31391-Ab-1/ GM-Tg-equg-T31391-Ab-2
Products NameAnti-DPP-4/DPP4 monoclonal antibody
Formatmab
Target NameDPP-4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-DPP-4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-054Pre-Made Begelomab biosimilar, Whole mAb, Anti-DPP4/DPP-4 Antibody: Anti-ADABP/ADCP2/CD26/DPPIV/TP103 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species DPP4/ DPP-4/ ADABP VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T31391-Ag-1dipeptidylpeptidase 4 (DPP4) protein
    ORF Viral VectorpGMAAV000048mouse Dpp4 AAV plasmid
    ORF Viral VectorvGMAAV000048mouse Dpp4 AAV particle


    Target information

    Target IDGM-T31391
    Target NameDPP-4
    Gene ID1803,13482,25253,654491,478767,493787,281122,100061124
    Gene Symbol and SynonymsACT3,ADABP,ADCP-I,ADCP2,CD26,Dpp-4,DPP4,DPPIV,THAM,TP103,WC10
    Uniprot AccessionP27487,P14740,Q9N2I7,P81425
    Uniprot Entry NameDPP4_HUMAN,DPP4_RAT,DPP4_FELCA,DPP4_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseProstate Cancer, Ureteral obstruction, Diabetic Nephropathy
    Gene EnsemblENSG00000197635
    Target ClassificationCheckpoint-Immuno Oncology

    The target: DPP-4, gene name: DPP4, also named as ADABP, ADCP2, CD26, DPPIV, TP103. The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.