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Anti-CRCM1/ CRACM/ ORAI1 monoclonal antibody
Anti-CRCM1/ CRACM/ ORAI1 antibody for FACS & in-vivo assay
Go to CRACM/ORAI1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30790-Ab-1/ GM-Tg-hg-T30790-Ab-2 | Anti-Human CRACM/ORAI1 monoclonal antibody | Human |
| GM-Tg-rg-T30790-Ab-1/ GM-Tg-rg-T30790-Ab-2 | Anti-Rat CRACM/ORAI1 monoclonal antibody | Rat |
| GM-Tg-mg-T30790-Ab-1/ GM-Tg-mg-T30790-Ab-2 | Anti-Mouse CRACM/ORAI1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T30790-Ab-1/ GM-Tg-cynog-T30790-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CRACM/ORAI1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30790-Ab-1/ GM-Tg-felg-T30790-Ab-2 | Anti-Feline CRACM/ORAI1 monoclonal antibody | Feline |
| GM-Tg-cang-T30790-Ab-1/ GM-Tg-cang-T30790-Ab-2 | Anti-Canine CRACM/ORAI1 monoclonal antibody | Canine |
| GM-Tg-bovg-T30790-Ab-1/ GM-Tg-bovg-T30790-Ab-2 | Anti-Bovine CRACM/ORAI1 monoclonal antibody | Bovine |
| GM-Tg-equg-T30790-Ab-1/ GM-Tg-equg-T30790-Ab-2 | Anti-Equine CRACM/ORAI1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30790-Ab-1/ GM-Tg-hg-T30790-Ab-2; GM-Tg-rg-T30790-Ab-1/ GM-Tg-rg-T30790-Ab-2; GM-Tg-mg-T30790-Ab-1/ GM-Tg-mg-T30790-Ab-2; GM-Tg-cynog-T30790-Ab-1/ GM-Tg-cynog-T30790-Ab-2; GM-Tg-felg-T30790-Ab-1/ GM-Tg-felg-T30790-Ab-2; GM-Tg-cang-T30790-Ab-1/ GM-Tg-cang-T30790-Ab-2; GM-Tg-bovg-T30790-Ab-1/ GM-Tg-bovg-T30790-Ab-2; GM-Tg-equg-T30790-Ab-1/ GM-Tg-equg-T30790-Ab-2 |
| Products Name | Anti-CRACM/ORAI1 monoclonal antibody |
| Format | mab |
| Target Name | CRACM |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CRACM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CRCM1/ CRACM/ ORAI1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001896 | human ORAI1 Lentivirus particle |
| ORF Viral Vector | pGMLP001896 | human ORAI1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004494 | mouse Orai1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004494 | mouse Orai1 Lentivirus particle |
Target information
| Target ID | GM-T30790 |
| Target Name | CRACM |
| Gene ID | 84876,109305,304496,700190,486261,101096922,517688,100059726 |
| Gene Symbol and Synonyms | CRACM1,D730049H07Rik,IMD9,orai-1,ORAI1,ORAT1,RGD1311873,TAM2,™EM142A |
| Uniprot Accession | Q96D31,Q5M848 |
| Uniprot Entry Name | CRCM1_HUMAN,CRCM1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000276045 |
| Target Classification | N/A |
The target: CRACM, gene name: ORAI1, also named as CRACM1, IMD9, ORAT1, TAM2, ™EM142A. The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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